Rabbit Anti-TXNRD1 Recombinant Antibody (clone R01-8I4) (CAT#: VS3-FY1923)
This R01-8I4 recombinant monoclonal antibody has been meticulously crafted to specifically target human TXNRD1. It cross-reacts with mouse. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF, IP. It is advised to dilute the sample for improved detectability by western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200), immunoprecipitation (dilution 1/20). The thioredoxin reductase 1 antibody is recommended for detection of target protein by western blot analysis of TXNRD1 in 3T3 lysates and immunohistochemistry analysis of paraffin-embedded human lung cancer antigen
retrieval.
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Custom Production
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WB
Figure 1 Anti-TXNRD1 Antibody (VS3-FY1923) in WB.
The TXNRD1 expression in 3T3 lysates were detected using the anti-Thioredoxin Reductase 1 by western blot assay.
IHC
Figure 2 Anti-TXNRD1 Antibody (VS3-FY1923) in IHC.
Immunohistochemistry staining of paraffin-embedded human lung cancer using the anti-TXNRD1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Specifications
- Immunogen
- Recombinant human TXNRD1 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse TXNRD1
- Species Reactivity
- Human, Mouse
- Clone
- R01-8I4
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 71 kDa, while the observed molecular weight stands at 55 kDa.
- Related Disease
- Human lung cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- Thioredoxin Reductase 1; Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein; Gene Associated With Retinoic And IFN-Induced Mortality 12 Protein; KM-102-Derived Reductase-Like Factor; Thioredoxin Reductase TR1; EC 1.8.1.9; GRIM-12; TR; Testis Tissue Sperm-Binding Protein Li 46a; Thioredoxin Reductase 1, Cytoplasmic
- Gene ID
- 7296
- UniProt ID
- Q16881
- Sequence Similarities
- Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- [Isoform 5]: The N-terminus is blocked. (Q16881-TRXR1_HUMAN)
ISGylated. (Q16881-TRXR1_HUMAN)
Ubiquitination at Lys179, Lys218, Lys274, Lys405, Lys449, Lys574, Lys580, Lys607, and Lys613 (NX_Q16881 [NX_Q16881-1])
Modification sites at PhosphoSitePlus (Q16881)
Glycosylation from GlyGen (Q16881) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001087240.1; NP_001248374.1; NP_001248375.1; NP_003321.3; NP_877393.1
- Function
- Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form.
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2050CT | Recombinant Mouse anti-Human TXNRD1 Monoclonal antibody (20B2) | ELISA, FC, ICC/IF, IP, WB | |
| MRO-1542-CN | Rabbit Anti-TXNRD1 Recombinant Antibody (clone JA11-32) | WB, IF, IHC, IP, FC | Rabbit IgG |
| VS3-WK1023 | Rabbit Anti-TXNRD1 Recombinant Antibody (VS3-WK1023) | WB, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
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