Rabbit Anti-TXNRD1 Recombinant Antibody (clone R01-8I4) (CAT#: VS3-FY1923)
This R01-8I4 recombinant monoclonal antibody has been meticulously crafted to specifically target human TXNRD1. It cross-reacts with mouse. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF, IP. It is advised to dilute the sample for improved detectability by western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200), immunoprecipitation (dilution 1/20). The thioredoxin reductase 1 antibody is recommended for detection of target protein by western blot analysis of TXNRD1 in 3T3 lysates and immunohistochemistry analysis of paraffin-embedded human lung cancer antigen
retrieval.
Specific Inquiry
WB
Figure 1 Anti-TXNRD1 Antibody (VS3-FY1923) in WB.
The TXNRD1 expression in 3T3 lysates were detected using the anti-Thioredoxin Reductase 1 by western blot assay.
IHC
Figure 2 Anti-TXNRD1 Antibody (VS3-FY1923) in IHC.
Immunohistochemistry staining of paraffin-embedded human lung cancer using the anti-TXNRD1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Specifications
- Immunogen
- Recombinant human TXNRD1 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse TXNRD1
- Species Reactivity
- Human, Mouse
- Clone
- R01-8I4
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 71 kDa, while the observed molecular weight stands at 55 kDa.
- Related Disease
- Human lung cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- Thioredoxin Reductase 1; Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein; Gene Associated With Retinoic And IFN-Induced Mortality 12 Protein; KM-102-Derived Reductase-Like Factor; Thioredoxin Reductase TR1; EC 1.8.1.9; GRIM-12; TR; Testis Tissue Sperm-Binding Protein Li 46a; Thioredoxin Reductase 1, Cytoplasmic
- Gene ID
- 7296
- UniProt ID
- Q16881
- Sequence Similarities
- Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- [Isoform 5]: The N-terminus is blocked. (Q16881-TRXR1_HUMAN)
ISGylated. (Q16881-TRXR1_HUMAN)
Ubiquitination at Lys179, Lys218, Lys274, Lys405, Lys449, Lys574, Lys580, Lys607, and Lys613 (NX_Q16881 [NX_Q16881-1])
Modification sites at PhosphoSitePlus (Q16881)
Glycosylation from GlyGen (Q16881) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001087240.1; NP_001248374.1; NP_001248375.1; NP_003321.3; NP_877393.1
- Function
- Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form.
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2050CT | Recombinant Mouse anti-Human TXNRD1 Monoclonal antibody (20B2) | ELISA, FC, ICC/IF, IP, WB | |
| MRO-1542-CN | Rabbit Anti-TXNRD1 Recombinant Antibody (clone JA11-32) | WB, IF, IHC, IP, FC | Rabbit IgG |
| VS3-WK1023 | Rabbit Anti-TXNRD1 Recombinant Antibody (VS3-WK1023) | WB, IHC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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