Rabbit Anti-TYR Recombinant Antibody (VS13-YC1194)
CAT#: VS13-YC1194
The Rabbit Anti-TYR Recombinant Antibody is specific for human TYR. The TYR gene encodes an enzyme that catalyzes steps in converting tyrosine to melanin and requires copper for function. Mutations can result in oculocutaneous albinism and affect skin pigmentation. The anti-TYR antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100), Immunofluorescence (1/50-1/200).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43241/1291_D5_4_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077498-TYR/subcellular
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Specifications
- Immunogen
- Recombinant human Tyrosinase.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TYR
- Species Reactivity
- Human
- Applications
- WB, IHC-P, ICC, IF
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Immunofluorescence (IF): 1/50-1/200
Target
- Alternative Names
- Tyrosinase; Oculocutaneous Albinism IA; Tumor Rejection Antigen AB; Monophenol Monooxygenase; EC 1.14.18.1; LB24-AB; SK29-AB;
- Gene ID
- 7299
- UniProt ID
- P14679
- Long Name
- Tyrosinase
- Sequence Similarities
- Belongs to the tyrosinase family.
- Cellular Localization
- Membrane
- Protein Refseq
- NP_000363.1
- Function
- This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity).
Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity).
In addition to hydroxylating tyrosine to DOPA (3, 4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5, 6-dihydroxyindole) to indole-5, 6 quinone (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Tyr"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1019-F(E) | Recombinant Anti-Tyr Antibody Fab Fragment | RIA, WB, FuncS | Fab |
| MHH-1019-F(E) | Recombinant Human Anti-Tyr Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1019-S(P) | Recombinant Anti-Tyr Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-1019-S(P) | Recombinant Human Anti-Tyr Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-1019 | Recombinant Human Anti-Tyr Antibody | RIA, IF, FuncS | IgG |
| MOB-0343MZ | Recombinant Mouse Anti-Human TYR Antibody (clone U312) | IHC | Mouse antibody |
| MRO-2248-CN | Rabbit Anti-TYR Polyclonal Antibody (MRO-2248-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0163C | Mouse Anti-TYR Recombinant Antibody (clone ABT-TYR) | IHC-P, IF | Mouse IgG |
| ZG-0164C | Mouse Anti-TYR Recombinant Antibody (clone PT1611) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3734 | Rabbit Anti-TYR Recombinant Antibody (clone DS3734AB) | IHC-P, WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ655 | Mouse Anti-TYR Recombinant Antibody (VS3-CJ655) | IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7664 | Anti-TYR Immunohistochemistry Kit | IHC | |
| VS-0525-XY7665 | Anti-Mouse TYR Immunohistochemistry Kit | IHC |
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