Rabbit Anti-ULK3 Recombinant Antibody (clone R08-7J3) (CAT#: VS3-FY1930)
This anti-ULK3 antibody detected positive in western blot analysis of ULK3 in K562, Hela lysates. The recombinant monoclonal antibody demonstrates high specificity in target human ULK3. This R08-7J3 antibody is validated for western blot analysis of ULK3 in K562, Hela lysates.
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WB
Figure 1 Anti-ULK3 Antibody (VS3-FY1930) in WB.
The ULK3 expression in K562, Hela lysates were detected using the anti-ULK3 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human ULK3
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human ULK3
- Species Reactivity
- Human
- Clone
- R08-7J3
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 53 kDa, while the observed molecular weight stands at 53 kDa.
- Related Disease
- Non-Syndromic X-Linked Intellectual Disability 97
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Unc-51 Like Kinase 3; Unc-51-Like Kinase 3 (C. Elegans); Unc-51-Like Kinase 3; EC 2.7.11.1
- Gene ID
- 25989
- UniProt ID
- Q6PHR2
- Sequence Similarities
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Autophosphorylated.
Autophosphorylation is blocked by interaction with SUFU.
(Q6PHR2-ULK3_HUMAN)
Ubiquitination at Lys345 (NX_Q6PHR2 [NX_Q6PHR2-1])
Modification sites at PhosphoSitePlus (Q6PHR2)
- Protein Refseq
- XP_005254346.1; XP_016877557.1; XP_047288324.1; XP_047288325.1; XP_047288326.1
- Function
- Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3789 | Rabbit Anti-ULK3 Recombinant Antibody (clone DS3789AB) | WB, IHC, ICC, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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