On the basis of Bevacizumab and an all-human monoclonal antibody B5E3, a two-epitope bispecific antibody Bev-B5E3BsAb targeting VEGF is constructed. Experiments show that the bispecific antibody does not compete with Bevacizumab to combine with VEGF, and it is speculated that the epitopes of the bispecific antibody are new epitopes different from those of Bevacizumab. Meanwhile, compared with two parent monoclonal antibodies of the bispecific antibody, the bispecific antibody can combine with VEGF more effectively. In addition, the bispecific antibody displays stronger ability in inhibiting proliferation of human umbilical vein endothelial cells (HUVEC) in experiments in vitro; animal experiments show that the bispecific antibody can remarkably inhibit growth of tumors. Therefore, the bispecific antibody is expected to be developed into a novel antibody reagent used for treatment or diagnosis of tumors and ophthalmic diseases.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H73 | Anti-Human VEGFA Recombinant Antibody (Vanucizumab) | WB, FC, IP, ELISA, Neut, FuncS, IF | VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa |
TAB-011 | Anti-Human VEGF Recombinant Antibody (Bevacizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
TAB-012-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (Ranibizumab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | Fab - G1 - kappa |
TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
TAB-009ML | Anti-Human VEGFA Recombinant Antibody scFv Fragment (Brolucizumab) | ELISA, IHC, FC, IP, IF, Inhib | scFv, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L043L | anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-358 | Human Anti-VEGFA Recombinant Antibody (clone 5A12); scFv Fragment | WB, ELISA, FuncS | Human scFv |
HPAB-S0151-YC-S(P) | Human Anti-VEGFA Recombinant Antibody (clone Y0238-3); scFv Fragment | ELISA, Inhib | Humanized scFv |
HPAB-S0152-YC-S(P) | Human Anti-VEGFA Recombinant Antibody (clone Y0243-1); scFv Fragment | ELISA, Inhib | Humanized scFv |
HPAB-1933-FY-F(E) | Human Anti-VEGFA Recombinant Antibody (clone Y0101); scFv Fragment | ELISA | Humanized scFv |
HPAB-1956-FY-S(P) | Human Anti-VEGFA Recombinant Antibody (clone Bh21-7); scFv Fragment | IF | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-075 | Mouse Anti-VEGFA Recombinant Antibody (clone YADS1); Fab Fragment | ELISA | Mouse Fab |
PFBC-076 | Mouse Anti-VEGFA Recombinant Antibody (clone YADS2); Fab Fragment | ELISA | Mouse Fab |
HPAB-M0242-YC-F(E) | Human Anti-VEGFA Recombinant Antibody (clone B5E3); Fab Fragment | ELISA | Humanized Fab |
HPAB-M0243-YC-F(E) | Human Anti-VEGFA Recombinant Antibody (clone Bev-B5E3BsAb); Fab Fragment | ELISA, Block, Inhib | Humanized Fab |
HPAB-0006-YJ-F(E) | Human Anti-VEGFA Recombinant Antibody (clone Y0317); Fab Fragment | ELISA, FuncS, In vivo | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-306CQ | Mouse Anti-VEGFA Recombinant Antibody (TAB-306CQ) | FuncS, Inhib | Mouse IgG |
TAB-306CQ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-306CQ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-306CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-306CQ-F(E)) | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-284CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-284CQ-S(P)) | ELISA | Human scFv |
TAB-304CQ-S(P) | Anti-Human VEGFA Recombinant Antibody scFv Fragment (2H1) | ELISA, WB | Human antibody |
TAB-305CQ-S(P) | Anti-Human VEGFA Recombinant Antibody scFv Fragment (2H1-32) | ELISA, WB | Human antibody |
TAB-284CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-284CQ-F(E)) | ELISA | Human Fab |
TAB-304CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1) | ELISA, WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0623MZ | Chicken Anti-VEGF Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2255CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL198) | Neut, WB | Mouse IgG1 |
NEUT-2256CQ | Rat Anti-Vegfa Recombinant Antibody (clone 2G11-2A05) | WB, Neut, ELISA, IHC, FuncS | Rat IgG2a, κ |
NEUT-2257CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 16F1) | WB, Neut | Mouse IgG2a |
NEUT-2258CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 4B2-8) | ELISA, Neut, WB | Mouse IgG1, κ |
NEUT-2260CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL737) | WB, ELISA, Neut | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2259CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A.4.6.1) | ELISA, IP, WB, Block, FC, IHC | Mouse IgG1, κ |
NEUT-2267CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A15136B) | WB, Block | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3835 | Rabbit Anti-VEGFA Recombinant Antibody (clone DS3835AB) | FC, ICC, IF, IHC-P, IP, WB | Rabbit IgG |
MOR-4758 | Rabbit Anti-Vegfa Recombinant Antibody (clone TH272DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MD-ZBF-YC024 | Camelid Anti-VEGFA Recombinant Single Domain Antibody (clone A80887) | ELlSA | Camelid VHH |
HPAB-N0310-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (V32R) | ELISA, FC, WB | Shark vNAR |
HPAB-N0311-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (V19) | ELISA, FC, WB | Shark vNAR |
HPAB-0337-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (V32R) | FC, ELISA, Inhib, Neut | Shark vNAR |
HPAB-0338-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (V19) | FC, ELISA, Inhib, Neut | Shark vNAR |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0330CQ | Mouse Anti-VEGFA Recombinant Antibody (clone mAb G6-31) | ELISA, IF, Block, FuncS | Chimeric (mouse/human) IgG |
HPAB-0348-WJ | Human Anti-VEGFA Recombinant Antibody (clone 7F2) | ELISA | Humanized IgG |
HPAB-0349-WJ | Human Anti-VEGFA Recombinant Antibody (clone 6B2) | ELISA | Humanized IgG |
HPAB-M0372-YC | Canine Anti-VEGFA Recombinant Antibody (HPAB-M0372-YC) | FuncS, Inhib | Chimeric (Mouse/Canine) IgGB, κ |
HPAB-M0373-YC | Canine Anti-VEGFA Recombinant Antibody (HPAB-M0373-YC) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) IgGB, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-465CQ | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Varisacumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-011 | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Bevacizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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