Recombinant Anti-VTCN1 (AA 167-176 x AA 177-181) Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC193)
This biparatopic antibody (bpAb) features tandem scFv arms that simultaneously bind with high affinity to two distinct VTCN1 epitopes: amino acids 167-176 and amino acids 177-181.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/1356_C9_3_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/1356_C9_3_selected.jpg

Figure 2 IHC staining of human breast
(Immunohistochemical staining of human breast shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/ihc_selected.jpg
(Immunohistochemical staining of human breast shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/ihc_selected.jpg

Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_9_3.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_9_3.jpg

Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_8_5.jpg

Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_4_6.jpg

Figure 6 Breast
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_B_3_4.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_B_3_4.jpg

Figure 7 Lymph node
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_7_8.jpg
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_7_8.jpg

Figure 8 RNA cell line category: Cell line enriched (SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134258-VTCN1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134258-VTCN1
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human VTCN1
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Epitope 1
- aa 167-176
- Epitope 2
- aa 177-181
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, FC
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- V-Set Domain Containing T Cell Activation Inhibitor 1
Target
- Introduction
- This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- V-Set Domain Containing T Cell Activation Inhibitor 1; Immune Costimulatory Protein B7-H4; B7 Superfamily Member 1; B7 Family Member, H4; B7 Homolog 4; B7-H4; B7h.5; B7H4; V-Set Domain-Containing T-Cell Activation Inhibitor 1;
- Gene ID
- 79679
- UniProt ID
- Q7Z7D3
Downloads
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Biparatopic Antibody (bpAb) Products
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2216z | Mouse Anti-VTCN1 Recombinant Antibody (clone 21A2) | WB, ELISA | Mouse IgG1 |
HPAB-0307-CN | Mouse Anti-VTCN1 Recombinant Antibody (HPAB-0307-CN) | ELISA, FC, IHC, IF | Mouse IgG |
HPAB-0335CQ | Human Anti-VTCN1 Recombinant Antibody (HPAB-0335CQ) | ELISA, FC | Human IgG1, κ |
HPAB-0336CQ | Human Anti-VTCN1 Recombinant Antibody (HPAB-0336CQ) | ELISA, FC | Human IgG1, κ |
HPAB-0337CQ | Human Anti-VTCN1 Recombinant Antibody (HPAB-0337CQ) | ELISA, FC | Human IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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