Rabbit Anti-VWF Recombinant Antibody (clone R01-5D2) (CAT#: VS3-FY1936)
The rabbit recombinant monoclonal antibody is ideal for use in WB, IHC assays. This antibody shows high affinity in binding to human and rat VWF. The recommended application dilution human and ratio is: western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_B_8_5.jpg
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_B_8_5.jpg
Figure 2 Colon
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_A_9_3.jpg
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_A_9_3.jpg
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000110799-VWF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000110799-VWF
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110799-VWF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110799-VWF
Specifications
- Immunogen
- Synthetic peptide of human von Willebrand factor
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat VWF
- Species Reactivity
- Human, Rat
- Clone
- R01-5D2
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- MW
- The calculated weight of the target protein is approximately 309 kDa, while the observed molecular weight stands at 309 kDa.
- Related Disease
- Occlusive disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Von Willebrand Factor; F8VWF; Coagulation Factor VIII VWF; VWD; VWF
- Gene ID
- 7450
- UniProt ID
- P04275
- Cellular Localization
- Extracellular matrix, Secreted
- Post Translation Modifications
- All cysteine residues are involved in intrachain or interchain disulfide bonds. (P04275-VWF_HUMAN)
N- and O-glycosylated. (P04275-VWF_HUMAN)
Glycosylation at Asn99, Asn156, Asn211, Asn368, Asn666, Asn857, Asn1147, Asn1231, Thr1248, Thr1255, Thr1256, Ser1263, Thr1468, Thr1477, Ser1486, Thr1487, Asn1515, Asn1574, Thr1679, Asn2223, Asn2290, Thr2298, Asn2357, Asn2400, Asn2546, Asn2585, and Asn2790 (NX_P04275 [NX_P04275-1])
Modification sites at PhosphoSitePlus (P04275)
Glycosylation from GlyConnect VWF_HUMAN (627)
Glycosylation from GlyGen (P04275) 30 sites, 112 N-linked glycans (12 sites), 10 O-linked glycans (8 sites)
- Protein Refseq
- XP_047285457.1; XP_054229108.1; NP_000543.3
- Function
- Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibodies
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Humanized Antibodies
Chimeric Antibodies
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Single Domain Antibodies
ScFv-Fc Chimeras
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1149z | Mouse Anti-VWF Recombinant Antibody (clone 41C2) | WB, FC, IF, IHC, IP | Mouse IgG1, κ |
| MOB-2032CT | Recombinant Mouse anti-Human VWF Monoclonal antibody (47C22) | IHC-Fr, IHC-P | |
| MRO-1590-CN | Rabbit Anti-VWF Recombinant Antibody (clone CBACN-582) | WB, IHC | Rabbit IgG |
| HPAB-0343-WJ | Mouse Anti-VWF Recombinant Antibody (HPAB-0343-WJ) | ELISA, WB | Mouse IgG |
| VS-0723-WK146 | Human Anti-VWF Recombinant Antibody (VS-0723-WK146) | FC | Chimeric (rabbit/human) IgG1 |
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