Rabbit Anti-VWF Recombinant Antibody (clone R01-5D2) (CAT#: VS3-FY1936)

• Immunogen
• Synthetic peptide of human von Willebrand factor

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat VWF

• Species Reactivity
• Human, Rat

• Clone
• R01-5D2

• Applications
• Western Blot, Immunohistochemistry-Paraffin

• MW
• The calculated weight of the target protein is approximately 309 kDa, while the observed molecular weight stands at 309 kDa.

• Related Disease
• Occlusive disease

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100

• Alternative Names
• Von Willebrand Factor; F8VWF; Coagulation Factor VIII VWF; VWD; VWF

• Gene ID
• 7450

• UniProt ID
• P04275

• Cellular Localization
• Extracellular matrix, Secreted

• Post Translation Modifications
• All cysteine residues are involved in intrachain or interchain disulfide bonds. (P04275-VWF_HUMAN)
  N- and O-glycosylated. (P04275-VWF_HUMAN)
  Glycosylation at Asn99, Asn156, Asn211, Asn368, Asn666, Asn857, Asn1147, Asn1231, Thr1248, Thr1255, Thr1256, Ser1263, Thr1468, Thr1477, Ser1486, Thr1487, Asn1515, Asn1574, Thr1679, Asn2223, Asn2290, Thr2298, Asn2357, Asn2400, Asn2546, Asn2585, and Asn2790 (NX_P04275 [NX_P04275-1])
  Modification sites at PhosphoSitePlus (P04275)
  Glycosylation from GlyConnect VWF_HUMAN (627)
  Glycosylation from GlyGen (P04275) 30 sites, 112 N-linked glycans (12 sites), 10 O-linked glycans (8 sites)

• Protein Refseq
• XP_047285457.1; XP_054229108.1; NP_000543.3

• Function
• Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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