Rabbit Anti-XRCC1 Recombinant Antibody (clone R05-7K6) (CAT#: VS3-XY3542)
It is a recombinant rabbit antibody specific for XRCC1 (X-ray repair cross complementing 1), which negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair. The antibody specifically targets human, mouse and rat XRCC1. This product has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat XRCC1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-7K6
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Spinocerebellar Ataxia
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- RCC; SCAR26
- Gene ID
- 7515
- UniProt ID
- P18887
- Long Name
- X-ray repair cross complementing 1
- Cellular Localization
- Nucleus, Chromosome
- Post Translation Modifications
- Sumoylated. (P18887-XRCC1_HUMAN)
Glycosylation at Thr296, Thr440, Ser446, Ser447, and Thr453 (NX_P18887 [NX_P18887-1])
Modification sites at PhosphoSitePlus (P18887)
Glycosylation from GlyGen (P18887) 6 sites, 2 O-linked glycans (6 sites)
- Protein Refseq
- NP_006288.2
- Function
- Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, 28002403).
Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:34102106, 34811483, 28002403).
Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3628z | Mouse Anti-XRCC1 Recombinant Antibody (clone 41H8) | WB, IP, IF, IHC, ELISA | Mouse IgG2b |
| MOB-2157CT | Recombinant Mouse anti-Human XRCC1 Monoclonal antibody (44-3-6) | FC, ICC/IF, IHC-Fr, IHC-P, IP, WB | |
| VS3-QX1251 | Mouse Anti-XRCC1 Recombinant Antibody (clone 3F6-G7-F7) | WB | Mouse IgG1 |
| VS7-0425-WR1136 | Mouse Anti-XRCC1 Recombinant Antibody (clone 7B4C12) | WB, IHC, FC | Mouse IgG1 |
| VS7-0425-WR1137 | Mouse Anti-XRCC1 Recombinant Antibody (clone 4D10D3) | WB, IHC, FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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