Anti-YWHAZ (clone W24V153) Recombinant Antibody Coupled Liposome (VS-1024-FY153) (CAT#: VS-1024-FY153)

• Potential Clinical Applications
• Colorectal cancer

• Clone
• W24V153

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that has been meticulously engineered to specifically recognize and bind to YWHAZ, a protein that plays a crucial role in various cellular processes. Our monoclonal antibody has been developed through advanced recombinant techniques, ensuring high specificity and affinity for YWHAZ. This targeted approach allows for precise detection and quantification of YWHAZ in various biological samples, making it an invaluable tool for research and diagnostic applications.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• YWHAZ

• Introduction
• This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.

• Alternative Names
• HEL4; YWHAD; KCIP-1; HEL-S-3; POPCHAS; HEL-S-93; 14-3-3-zeta

• Full Name
• Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta

• Gene ID
• 7534

• UniProt ID
• P63104

• Sequence Similarities
• Belongs to the 14-3-3 family.

• Cellular Localization
• Cytoplasm; Melanosome

• Post Translation Modifications
• The delta, brain-specific form differs from the zeta form in being phosphorylated (Probable).
  Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria (PubMed:15071501, 15696159).
  Phosphorylation on Thr-232; inhibits binding of RAF1.

• Protein Refseq
• XP_005251118.1; XP_005251120.1; XP_016869299.1; XP_016869300.1; XP_054217157.1

• Function
• Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396).
  Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396).
  Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB.

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