Rabbit Anti-ZBTB33 Recombinant Antibody (VS13-YC1238) (CAT#: VS13-YC1238)

• Immunogen
• Recombinant human KAISO.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat ZBTB33

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB

• Conjugate
• NONE

• Related Disease
• Cri-Du-Chat Syndrome

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 10 mM PBS (pH 7.4) containing 150 mM NaCl, 50% Glycerol and 0.05% BSA.

• Preservative
• 0.02% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000

• Alternative Names
• Zinc Finger And BTB Domain Containing 33; Zinc Finger And BTB Domain-Containing Protein 33; ZNF348; Transcriptional Regulator Kaiso; Kaiso Transcription Factor; WUGSC: H_DJ525N14.1; ZNF-Kaiso; KAISO;

• Gene ID
• 10009

• UniProt ID
• Q86T24

• Long Name
• Zinc Finger And BTB Domain Containing 33

• Cellular Localization
• Cytoplasm; Nucleus

• Protein Refseq
• NP_001171671.1; NP_006768.1

• Function
• Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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