APC-DRB1*07:01/Human HA (PKYVKQNTLKLAT) MHC Tetramer
CAT#: MHC-YF1043
This product is a MHC tetramer of biotinylated peptide/MHC complex composed HA-derived peptide of PKYVKQNTLKLAT sequence covering 307-319 and DRB1*07:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*07:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- HA
- Antigen Species
- Influenza A
- Peptide
- PKYVKQNTLKLAT
- Range
- 307-319
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
- Alternative Names
- Hemagglutinin; HA
- Gene ID
- 3654620
- UniProt ID
- P03452
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