APC-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer

Name: APC-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer
SKU: MHC-CN0129
Rating: 5 (1 reviews)

CAT#: MHC-CN0129

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line PC-3

Immunofluorescent staining of human cell line PC-3 shows localization to nuclear speckles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6523/1905_E12_1_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human epididymis

Immunohistochemical staining of human epididymis shows strong nuclear membrane positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6660/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 3 IHC staining of human rectum

Immunohistochemical staining of human rectum shows strong nuclear membrane positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/ihc_selected.jpg

Normal Tissue Figure 4 Cerebral cortex

Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_8_5.jpg

Normal Tissue Figure 5 Colon

Endocrine cells
Staining: High
Intensity: Strong
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Fibroblasts
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_9_3.jpg

Normal Tissue Figure 6 Liver

Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_4.jpg

Normal Tissue Figure 7 Kidney

Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_8_5.jpg

Normal Tissue Figure 8 Testis

Leydig cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peritubular cells
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_6_6.jpg

Normal Tissue Figure 9 Skin

Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in granular layer
Staining: High
Intensity: Strong
Quantity: 75%-25%
Cells in spinous layer
Staining: High
Intensity: Strong
Quantity: 75%-25%
Endothelial cells
Staining: High
Intensity: Strong
Fibrohistiocytic cells
Staining: High
Intensity: Strong
Langerhans cells
Staining: High
Intensity: Strong
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_9_1.jpg

Normal Tissue Figure 10 Lymph node

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_8.jpg

RNA Expression Figure 11 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160789-LMNA

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Specifications

Allele
B*58:01

Class
Class I

MHC Species
Human

Antigen
Lamin

Antigen Species
Human

Peptide
KAGQVVTIW

Conjugate
APC

Application
FCM

Target

Antigen Introduction
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Alternative Names
LMNA; Lamin-A/C; FPL; IDC; LFP; CDDC; EMD2; FPLD

Gene ID
4000

UniProt ID
P02545

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Datasheet

Datasheet - MHC-CN0129.pdf

MSDS

MSDS - MHC-CN0129.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
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