BV421-DRB1*04:01/Human Proinsulin (GIVEQCCTSICSLYQ) MHC Tetramer
CAT#: MHC-YF1453
This product is a MHC tetramer of biotinylated peptide/MHC complex composed Proinsulin-derived peptide of GIVEQCCTSICSLYQ sequence covering 90-104 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Proinsulin
- Antigen Species
- Human
- Peptide
- GIVEQCCTSICSLYQ
- Range
- 90-104
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Alternative Names
- IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Gene ID
- 3630
- UniProt ID
- P01308
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