BV421-DRB1*11:01/Human Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Tetramer
CAT#: MHC-YF1433
This product is a MHC tetramer of biotinylated peptide/MHC complex composed Factor VIII-derived peptide of ENIQRFLPNPAGVQLEDPEF sequence covering 589-608 and DRB1*11:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*11:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Factor VIII
- Peptide
- ENIQRFLPNPAGVQLEDPEF
- Range
- 589-608
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
- Alternative Names
- AHF; F8B; F8C; HEMA; FVIII; DXS1253E
- Gene ID
- 2157
- UniProt ID
- P00451
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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