BV421-HLA-A*02:01/Human hTERT D988Y (YLQVNSLQTV) MHC Tetramer
CAT#: MHC-YF1564
This product is a MHC tetramer of biotinylated peptide/MHC complex composed hTERT D988Y-derived peptide of YLQVNSLQTV sequence covering 988-997 and HLA-A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- HLA-A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- hTERT D988Y
- Antigen Species
- Human
- Peptide
- YLQVNSLQTV
- Range
- 988-997
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
- Alternative Names
- TERT; telomerase reverse transcriptase; TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; hTERT
- Gene ID
- 7015
- UniProt ID
- O14746
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