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Anti-LAMP1 (clone chMAbl)-SPDB-DM4 ADC (CAT#: ADC-126CL)

This ADC product is composed of an anti-LAMP1 antibody (clone chMAbl) conjugated via SPDB linker to DM4(chMAbl-SPDB-DM4). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 Ihc staining of human urinary bladder
Figure 1 Ihc staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows strong granular positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14750/34136_A_5_5_selected.jpg
Figure 2 IHC staining of human colon
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity(granular pattern) in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/ihc_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_B_9_5.jpg
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_4.jpg
Figure 5 Pancreas
Figure 5 Pancreas
(Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_1_3.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_7_5.jpg
Figure 7 Testis
Figure 7 Testis
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_6_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185896-LAMP1

Specifications

  • Antibody Overview
  • Anti-LAMP1 Antibody, Chimeric mAb (chMAbl)
  • Clone
  • chMAbl
  • Linker
  • SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
  • Linker Class/Description
  • Class: Chemically cleavable linkers-Disulfide Linkers
    Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • LAMP1; lysosomal-associated membrane protein 1; LAMPA; CD107a; LGP120; lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1;

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Recombinant Antibody

CAT Product Name Application Type
MOB-611 Recombinant Anti-human LAMP1 Antibody ELISA, WB, FC, FuncS IgG
HPAB-0035-LSX Human Anti-LAMP1 Recombinant Antibody (HPAB-0035-LSX) ELISA, IHC, ADCC Human IgG
HPAB-0036-LSX Human Anti-LAMP1 Recombinant Antibody (HPAB-0036-LSX) ELISA, IHC, ADCC, FuncS Human IgG
HPAB-0037-LSX Human Anti-LAMP1 Recombinant Antibody (HPAB-0037-LSX) ELISA, IHC Chimeric (mouse/human) IgG
HPAB-0038-LSX Human Anti-LAMP1 Recombinant Antibody (HPAB-0038-LSX) ELISA, IHC, FC, ADCC, FuncS Human IgG

scFv Fragment Antibody

CAT Product Name Application Type
MOB-611-S(P) Recombinant Anti-human LAMP1 Antibody scFv Fragment IP, IF, Biosensors, FuncS scFv
MHH-611-S(P) Recombinant Human Anti-human LAMP1 Antibody scFv Fragment ELISA, WB, FC, FuncS scFv
HPAB-0035-LSX-S(P) Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0035-LSX-S(P)) ELISA, IHC Human scFv
HPAB-0036-LSX-S(P) Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0036-LSX-S(P)) ELISA, IHC Human scFv
HPAB-0037-LSX-S(P) Mouse Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0037-LSX-S(P)) ELISA, IHC Mouse scFv

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2010 Hi-Affi™ Recombinant Rabbit Anti-LAMP1 Monoclonal Antibody (DS2010AB) WB, IHC IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0035-LSX-F(E) Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0035-LSX-F(E)) ELISA, IHC Chimeric (mouse/human) Fab
HPAB-0036-LSX-F(E) Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0036-LSX-F(E)) ELISA, IHC Chimeric (mouse/human) Fab
HPAB-0037-LSX-F(E) Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0037-LSX-F(E)) ELISA, IHC Chimeric (mouse/human) Fab
HPAB-0038-LSX-F(E) Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0038-LSX-F(E)) ELISA, IHC Human Fab
HPAB-0039-LSX-F(E) Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0039-LSX-F(E)) ELISA, IHC Humanized Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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