DRB1*03:01/Human E2 (MEAIAKRLDACQDQLLELYE) MHC Tetramer
CAT#: MHC-YF876
This product is a MHC tetramer of biotinylated peptide/MHC complex composed E2-derived peptide of MEAIAKRLDACQDQLLELYE sequence covering 1-20 and DRB1*03:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*03:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- E2
- Antigen Species
- HPV
- Peptide
- MEAIAKRLDACQDQLLELYE
- Range
- 1-20
- Application
- FCM
Target
- Antigen Introduction
- Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
- Alternative Names
- Regulatory protein E2; E2
- Gene ID
- 1489080
- UniProt ID
- P03120
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