DRB1*03:01/HPV E2 (PIVQLQGDSNCLKCFR) MHC Monomer
CAT#: MHC-YF094
This product is a MHC monomer of biotinylated peptide/MHC complex composed E2-derived peptide of PIVQLQGDSNCLKCFR sequence covering 285-300 and DRB1*03:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*03:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- E2
- Antigen Species
- HPV
- Peptide
- PIVQLQGDSNCLKCFR
- Range
- 285-300
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
- Alternative Names
- Regulatory protein E2; E2
- Gene ID
- 1489080
- UniProt ID
- P03120
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