DRB1*04:01/Human GAD65 (KGMAALPRLIAFTSEHSHFS) MHC Monomer (CAT#: MHC-YF035)

• Allele
• DRB1*04:01

• Class
• Class II

• MHC Species
• Human

• Antigen
• GAD65

• Antigen Species
• Human

• Peptide
• KGMAALPRLIAFTSEHSHFS

• Range
• 265–284

• Conjugate
• Biotin

• Application
• MHC Multimer

• Antigen Introduction
• This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

• Alternative Names
• GAD65

• Gene ID
• 2572

• UniProt ID
• Q05329

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