DRB1*04:01/Human GAD65 (NFIRMVISNPAAT) MHC Monomer
CAT#: MHC-YF033
This product is a MHC monomer of biotinylated peptide/MHC complex composed GAD65-derived peptide of NFIRMVISNPAAT sequence covering 555-567 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_B_9_5.jpg
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Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- GAD65
- Antigen Species
- Human
- Peptide
- NFIRMVISNPAAT
- Range
- 555-567
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
- Alternative Names
- GAD65
- Gene ID
- 2572
- UniProt ID
- Q05329
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Reliable for T-Cell Profiling
Incorporating this monomer into our flow cytometry panels consistently yields reliable data. It precisely identifies GAD65-specific T-cells, underscoring its value in profiling autoreactive T-cell populations, crucial for validating therapeutic interventions.
Excels in Multi-Parameter Flow Cytometry
The capability to integrate this monomer in multi-color flow assays allows comprehensive profiling of T-cell phenotypes. It's become an essential tool for dissecting complex immune interactions and understanding regulatory versus effector T-cell roles.
Q&As
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What is the primary research application of the DRB104:01/Human GAD65 MHC Monomer?*
A: This MHC monomer is primarily used for studying autoimmune conditions like type 1 diabetes, by isolating and analyzing T-cells specific to the GAD65 (555-567) peptide. It is crucial for understanding immune responses involved in the pathogenesis of this disease.
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Can it be combined with other T-cell markers for flow cytometry?
A: The monomer that we provide is conjugated with biotin, it may be compatible with other common fluorophores and can be used alongside markers for differentiation (e.g., CD4, CD8) or activation (e.g., CD69, CD25) in multi-parameter flow cytometry analyses.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| MOR-1389 | Hi-Affi™ Rabbit Anti-GAD2 Recombinant Antibody (clone DS1389AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| MHC-CN0697 | PE-DRB1*04:01/Human GAD2 (IAFTSEHSHFSLK) MHC Tetramer | FCM, IHC | |
| MHC-CN0698 | APC-DRB1*04:01/Human GAD2 (IAFTSEHSHFSLK) MHC Tetramer | FCM, IHC | |
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| MHC-CN0701 | PE-DRB1*04:01/Human GAD2 (NFIRMVISNPAAT) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| HPAB-1982-FY-F(E) | Human Anti-GAD2 Recombinant Antibody (clone b78); Fab Fragment | Inhib | Human Fab, λ |
| CAT | Product Name | Application | Type |
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| HPAB-1982-FY-S(P) | Human Anti-GAD2 Recombinant Antibody (clone b78); scFv Fragment | Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF030 | DRB1*04:01/Human GAD65 (IAFTSEHSHFSLK) MHC Monomer | MHC Multimer | |
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| MHC-YF035 | DRB1*04:01/Human GAD65 (KGMAALPRLIAFTSEHSHFS) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
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| VS-0724-YC793 | AbPlus™ Anti-GAD2 Magnetic Beads (VS-0724-YC793) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
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