DRB1*04:01/Human GAD65 (NFIRMVISNPAAT) MHC Monomer
CAT#: MHC-YF033
This product is a MHC monomer of biotinylated peptide/MHC complex composed GAD65-derived peptide of NFIRMVISNPAAT sequence covering 555-567 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.



Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- GAD65
- Antigen Species
- Human
- Peptide
- NFIRMVISNPAAT
- Range
- 555-567
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
- Alternative Names
- GAD65
- Gene ID
- 2572
- UniProt ID
- Q05329
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Q&As
-
What is the primary research application of the DRB104:01/Human GAD65 MHC Monomer?*
A: This MHC monomer is primarily used for studying autoimmune conditions like type 1 diabetes, by isolating and analyzing T-cells specific to the GAD65 (555-567) peptide. It is crucial for understanding immune responses involved in the pathogenesis of this disease.
-
Can it be combined with other T-cell markers for flow cytometry?
A: The monomer that we provide is conjugated with biotin, it may be compatible with other common fluorophores and can be used alongside markers for differentiation (e.g., CD4, CD8) or activation (e.g., CD69, CD25) in multi-parameter flow cytometry analyses.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
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COA
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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