DRB1*04:01/Human GAD65 (NFIRMVISNPAAT) MHC Monomer

CAT#: MHC-YF033

This product is a MHC monomer of biotinylated peptide/MHC complex composed GAD65-derived peptide of NFIRMVISNPAAT sequence covering 555-567 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

Gene Expression
Figure 1 Cerebral cortex Figure 2 Pancreas Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)

Specifications

  • Allele
  • DRB1*04:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • GAD65
  • Antigen Species
  • Human
  • Peptide
  • NFIRMVISNPAAT
  • Range
  • 555-567
  • Conjugate
  • Biotin

Target

  • Antigen Introduction
  • This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
  • Alternative Names
  • GAD65
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Breast cancer biomarkers at key points during disease progression
Reliable for T-Cell Profiling
Incorporating this monomer into our flow cytometry panels consistently yields reliable data. It precisely identifies GAD65-specific T-cells, underscoring its value in profiling autoreactive T-cell populations, crucial for validating therapeutic interventions.
Breast cancer biomarkers at key points during disease progression
Excels in Multi-Parameter Flow Cytometry
The capability to integrate this monomer in multi-color flow assays allows comprehensive profiling of T-cell phenotypes. It's become an essential tool for dissecting complex immune interactions and understanding regulatory versus effector T-cell roles.

Q&As

  1. What is the primary research application of the DRB104:01/Human GAD65 MHC Monomer?*

    A: This MHC monomer is primarily used for studying autoimmune conditions like type 1 diabetes, by isolating and analyzing T-cells specific to the GAD65 (555-567) peptide. It is crucial for understanding immune responses involved in the pathogenesis of this disease.

  2. Can it be combined with other T-cell markers for flow cytometry?

    A: The monomer that we provide is conjugated with biotin, it may be compatible with other common fluorophores and can be used alongside markers for differentiation (e.g., CD4, CD8) or activation (e.g., CD69, CD25) in multi-parameter flow cytometry analyses.

View the frequently asked questions answered by Creative Biolabs Support.

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