DRB1*04:01/Human GAD65 (NFIRMVISNPAAT) MHC Monomer (CAT#: MHC-YF033)

This product is a MHC monomer of biotinylated peptide/MHC complex composed GAD65-derived peptide of NFIRMVISNPAAT sequence covering 555-567 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

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Custom Production

MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

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Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

We require custom production
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Allele
  • DRB1*04:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • GAD65
  • Antigen Species
  • Human
  • Peptide
  • NFIRMVISNPAAT
  • Range
  • 555-567
  • Conjugate
  • Biotin
  • Application
  • MHC Multimer

Target

  • Antigen Introduction
  • This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
  • Alternative Names
  • GAD65

Related Resources

  • Related Diseases

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Reliable for T-Cell Profiling
Incorporating this monomer into our flow cytometry panels consistently yields reliable data. It precisely identifies GAD65-specific T-cells, underscoring its value in profiling autoreactive T-cell populations, crucial for validating therapeutic interventions.

Excels in Multi-Parameter Flow Cytometry
The capability to integrate this monomer in multi-color flow assays allows comprehensive profiling of T-cell phenotypes. It's become an essential tool for dissecting complex immune interactions and understanding regulatory versus effector T-cell roles.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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