DRB1*04:01/Human Tyrp1 (ISPNSVFSQWRVVCDSLEDYD) MHC Tetramer
CAT#: MHC-YF853
This product is a MHC tetramer of biotinylated peptide/MHC complex composed Tyrp1-derived peptide of ISPNSVFSQWRVVCDSLEDYD sequence covering 277-297 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1291_B1_3_selected.jpg
Normal Tissue
Figure 2 Skin
Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1995_B_9_1.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107165-TYRP1/subcellular
❮
❯
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Tyrp1
- Antigen Species
- Human
- Peptide
- ISPNSVFSQWRVVCDSLEDYD
- Range
- 277-297
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
- Alternative Names
- TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
- Gene ID
- 7306
- UniProt ID
- P17643
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Stable and useful
Storage and handling are straightforward, and the product remains stable over extended periods. The conjugated fluorochromes are bright and compatible with our multicolor flow cytometry panels.
No cross-reactivity
We observed no cross-reactivity, which maintained the integrity and specificity of our experiments. This has been invaluable for our studies on autoimmune responses.
High affinity in complex cell mixtures
The instructions provided were clear and easy to follow. The tetramer performed as expected, showing high affinity even in complex cell mixtures, which is crucial for our cancer immunology research.
Q&As
-
Exist any recognized restrictions on using it for particular types of research?
A: While this MHC tetramer is required for studying peptide-specific T cells, it is only appropriate to research mice expressing the DRB1*04:01 allele and responding to the Human Tyrp1 peptide.
-
Is there any evidence of cross-reactivity between the DRB1*04:01/Human Tyrp1 MHC Tetramer and other HLA-DR alleles?
A: There was no discernible significant cross-reactivity. When it comes to the DRB1*04:01 allele, which encodes the Human Tyrp1 epitope, the tetramer is extremely specific.
-
When using the Tetramer, are there any biosafety considerations that researchers should be aware of?
A: Standard lab biosafety precautions should be followed. As with other chemicals, adequate PPE should be used, and precautions should be taken to avoid inhalation, ingestion, or skin and eye contact.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
MSDS
COA
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