DRB1*04:01/Human Tyrp1 (ISPNSVFSQWRVVCDSLEDYD) MHC Tetramer (CAT#: MHC-YF853)
This product is a MHC tetramer of biotinylated peptide/MHC complex composed Tyrp1-derived peptide of ISPNSVFSQWRVVCDSLEDYD sequence covering 277-297 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specific Inquiry
Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1291_B1_3_selected.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1291_B1_3_selected.jpg
Figure 2 Skin
(Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1995_B_9_1.jpg
(Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1995_B_9_1.jpg
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107165-TYRP1/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107165-TYRP1/subcellular
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Tyrp1
- Antigen Species
- Human
- Peptide
- ISPNSVFSQWRVVCDSLEDYD
- Range
- 277-297
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
- Alternative Names
- TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
- Gene ID
- 7306
- UniProt ID
- P17643
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1020-F(E) | Recombinant Anti-human TYRP1 Antibody Fab Fragment | ELISA, FuncS | Fab |
| MHH-1020-F(E) | Recombinant Human Anti-human TYRP1 Antibody Fab Fragment | IF, FACS, FuncS | Fab |
| HPAB-0121-LSX-F(E) | Human Anti-TYRP1 Recombinant Antibody (clone 20D7); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0122-LSX-F(E) | Human Anti-TYRP1 Recombinant Antibody (clone 20D7S); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0123-LSX-F(E) | Human Anti-TYRP1 Recombinant Antibody (clone CTA99); Fab Fragment | ELISA, FC | Mouse Fab |
Customer Reviews and Q&As
Customer Review
Q&As
Stable and useful
Storage and handling are straightforward, and the product remains stable over extended periods. The conjugated fluorochromes are bright and compatible with our multicolor flow cytometry panels.
No cross-reactivity
We observed no cross-reactivity, which maintained the integrity and specificity of our experiments. This has been invaluable for our studies on autoimmune responses.
High affinity in complex cell mixtures
The instructions provided were clear and easy to follow. The tetramer performed as expected, showing high affinity even in complex cell mixtures, which is crucial for our cancer immunology research.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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