H-2 IAb/Mouse Murine class II-associated invariant chain peptide (CLIP) (PVSQMRMATPLLMRP) MHC Tetramer
CAT#: MHC-YF902
This product is a MHC tetramer of biotinylated peptide/MHC complex composed Murine class II-associated invariant chain peptide (CLIP)-derived peptide of PVSQMRMATPLLMRP sequence covering 86-100 and H-2 IAb molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2 IAb
- Class
- Class II
- MHC Species
- Mouse
- Antigen
- Murine class II-associated invariant chain peptide (CLIP)
- Antigen Species
- Human
- Peptide
- PVSQMRMATPLLMRP
- Range
- 86-100
- Application
- FCM
Target
- Antigen Introduction
- The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- CLIP1; CAP-Gly domain containing linker protein 1; RSN; CLIP; CYLN1; CLIP170; CLIP-170
- Gene ID
- 6249
- UniProt ID
- P30622
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Supports Immunological Studies
This tetramer has played a pivotal role in our T cell research, particularly in identifying and analyzing CD4+ T cell responses. Its application in flow cytometry is seamless, providing accurate and insightful results.
Reliable Performance
The tetramer's consistent performance has offered dependable data across various experimental setups, from basic immunology to complex disease modeling, ensuring our research remains firmly grounded in quality results.
Q&As
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What makes the CLIP 86-100 sequence significant in this MHC tetramer?
A: The CLIP 86-100 sequence serves as a placeholder peptide, crucial for studying antigen processing pathways and loading mechanisms in MHC class II molecules, shedding light on adaptive immune responses.
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How does this tetramer contribute to cancer research?
A: It helps analyze CD4+ T cell populations in the tumor microenvironment, offering insights into how helper T cell responses can be modulated for effective cancer immunotherapy.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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