H-2Db/Influenza A NP (ASNENMETM) MHC Pentamer (CAT#: MHC-YF591)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed NP-derived peptide of ASNENMETM sequence covering 366-374 and H-2Db molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
Specific Inquiry
Specifications
- Allele
- H-2Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- NP
- Antigen Species
- Influenza A
- Peptide
- ASNENMETM
- Range
- 366-374
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
- Alternative Names
- Nucleoprotein; NP; N; Protein N; Nucleocapsid protein
- Gene ID
- 956531
- UniProt ID
- P03466
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IgM Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-094 | Mouse Anti-NP Recombinant Antibody (clone N1G9) | WB, ELISA | Mouse IgG |
| HPAB-0619-YJ | Mouse Anti-NP Recombinant Antibody (clone 9T13) | ELISA | Mouse IgG |
| HPAB-0620-YJ | Mouse Anti-NP Recombinant Antibody (clone 6T3) | ELISA | Mouse IgG |
| FAMAB-0072JF | Mouse Anti-NP Recombinant Antibody (clone 1A8) | WB, IF | Mouse IgM |
| FAMAB-1402CQ | Mouse Anti-NP Recombinant Antibody (clone aNP-VHH1) | IP, Neut, WB, FC, IF | Mouse IgG1 |
Customer Reviews and Q&As
Customer Review
Q&As
Unparalleled specificity and reliability
The H-2Db/Influenza A NP MHC Pentamer has been instrumental in my T-cell epitope mapping studies. The specificity and reliability of this reagent are unparalleled, enabling detailed dissections of immune responses.
Easy-to-follow protocols
The pentamer's easy-to-follow protocols and robust performance have made it an essential tool for my dissertation on T-cell mediated immunity. It's truly a researcher-friendly product.
Precise and deep data
Using this pentamer has significantly improved our regulatory testing for influenza vaccines. The precision and depth of data we can now gather are absolutely critical for safety and efficacy evaluations.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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