H-2Kd/Mouse Surface IgG of A20 (DYWGQGTEL) MHC Pentamer (CAT#: MHC-YC100)

MHC multimers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a Pentamer of peptide/MHC complex with Mouse-derived peptide of DYWGQGTEL sequence covering 106-114 and H-2Kd molecule. The peptide/MHC pentamer provided here is unlabeled or fluorescent labeled such as Biotin, R-PE, APC. And all of them are available in 50, 150 or 500 tests.

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Custom Production

MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

Peptide Sequence *:
Allele Requested *:
Antigen Species:
Antigen Molecule:
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Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

We require custom production
  • Datasheet
  • MSDS
  • COA

Specifications

  • Allele
  • H-2Kd
  • Class
  • Class I
  • MHC Species
  • Mouse
  • Antigen
  • Mouse Surface IgG of A20
  • Antigen Species
  • Mouse
  • Peptide
  • DYWGQGTEL
  • Range
  • 106-114
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • The hypervariable regions (idiotypes) of the surface immunoglobulin (Ig) B-cell receptor (Ig-BCR) expressed by lymphoma cells result from the rearrangement of the Igs genes and are unique for a given clonal B cell population. In this settings, the idiotypic determinants of the IgBCR expressed by lymphoma cells function as a specific tumor antigens that may be exploited for cell-specific targeted therapy12. Inoculation of the Id-peptide in A20-engrafted mice caused apoptosis of tumor cells and resulted in
    tumor growth inhibition and extended survival of diseased animals.
  • Alternative Names
  • Surface IgG of A20; Surface IgG (sA20-Ig) of A20 B-lymphoma cell line

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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