Anti-CD70 (h1F6)-β-glucuronide-MMAF ADC (CAT#: ADC-081LCT)

• Antibody Overview
• 1F6 (Humanized Anti-CD70)

• Clone
• h1F6

• Antibody Isotype
• IgG1

• Linker
• β-glucuronide linker

• Linker Class/Description
• β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;

• Gene ID
• 970

• UniProt ID
• P32970

• ADC-071LCT
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