Anti-CD33 (clone h2H12ec)-mc-vc-PBD ADC (CAT#: ADC-044LZY)

• Antibody Overview
• Humanized Anti-CD33 mAb with 2 engineered Cysteine residues,h2H12ec

• Clone
• h2H12ec

• Linker
• mc-VC (maleimidocaproyl-valine-alanine)

• Linker Class/Description
• Class: peptide linker
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• pyrrolobenzodiazepine (PBD) dimers

• Drug Class/Description
• Class: pyrrolobenzodiazepine (PBD) dimers
  Description: Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

• Introduction
• CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

• Alternative Names
• CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;

• Gene ID
• 945

• UniProt ID
• P20138

• ADC-L033
• Anti-CD33 (h2H12ec)-Mc-vc-PBD ADC (SGN-CD33A)

Select a product category from the dropdown menu below to view related products.