Anti-CD22 (clone hLL2)-SN-38 ADC (CAT#: ADC-124CL)

• Antibody Overview
• Humanized Antibody, hLL2 (Anti-CD22)

• Clone
• hLL2

• Drug
• SN-38 (7-ethyl-10-hydroxycamptothecin)

• Drug Class/Description
• Class: SN38
  Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.

• Introduction
• CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

• Alternative Names
• CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;

• Gene ID
• 933

• UniProt ID
• P20273

• TAB-0196CL
• Anti-Human CD22 Recombinant Antibody (hLL2)

• TAB-0196CL-S(P)
• Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2)

• TAB-0196CL-F(E)
• Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2)

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