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Anti-CEACAM6-CL2A-SN-38 ADC (CAT#: ADC-147LZY)

This ADC product is composed of an anti-CEACAM6 antibody conjugated via CL2A linker to SN-38 (CL2A-SN-38). It has demonstrated a response in breast tumors treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase I and causing DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 IHC staining of human duodenum
Figure 1 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/ihc_selected.jpg
Figure 2 High expression in lung.
Figure 2 High expression in lung.
(Macrophages Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_3_4.jpg
Figure 3 Colon
Figure 3 Colon
(Enterocytes - Microvilli Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_9_3.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Figure 5 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000086548-CEACAM6

Specifications

  • Antibody Overview
  • Humanized Anti-CEACAM6 mAb
  • Linker
  • CL2A
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • SN-38(7-ethyl-10-hydroxy camptothecin)
  • Drug Class/Description
  • Class: SN-38
    Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1

Target

  • Introduction
  • This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohns disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
  • Alternative Names
  • CEACAM6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); NCA; CEAL; CD66c; carcinoembryonic antigen-related cell adhesion molecule 6; normal cross-reacting antigen; Cluster of Differentiation 66c;

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Recombinant Antibody

CAT Product Name Application Type
MOB-1445z Mouse Anti-CEACAM6 Recombinant Antibody (clone 29F3) WB, IP, IF, IHC, FC Mouse IgG1, κ
MOB-2496MZ Recombinant Mouse Anti-Human CEACAM6 Antibody (clone 0B7) IHC-Fr, IHC-P, WB Mouse antibody
HPAB-N0336-YC Human Anti-CEACAM6 Recombinant Antibody (HPAB-N0336-YC) FC, ELISA Humanized IgG
HPAB-N0045-YC Mouse Anti-CEACAM6 Recombinant Antibody (HPAB-N0045-YC) FC, WB, IP Mouse IgG1, κ
VS-0723-WK31 Human Anti-CEACAM6 Recombinant Antibody (clone Tinurilimab) ELISA, FC Human IgG2

Single-domain Antibody

CAT Product Name Application Type
NABG-042 Recombinant Anti-Human CEACAM6 VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH
TAB-004LC-VHH Anti-Human CEACAM6 Recombinant Antibody (2A3) ELISA, WB, FC, Inhib, FuncS, ICC, SPR Single domain antibody

Mouse Antibody

CAT Product Name Application Type
TAB-445LC Mouse Anti-CEACAM6 Recombinant Antibody (TAB-445LC) ELISA, FC, IHC Mouse IgG1, κ
TAB-445LC-S(P) Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (TAB-445LC-S(P)) ELISA, FC Mouse scFv
TAB-477MZ Mouse Anti-CEACAM6 Recombinant Antibody (TAB-477MZ) ELISA, FuncS Mouse IgG
TAB-477MZ-F(E) Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-477MZ-F(E)) ELISA Mouse Fab
TAB-478MZ-F(E) Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-478MZ-F(E)) ELISA Mouse Fab

Humanized Antibody

CAT Product Name Application Type
TAB-444LC-F(E) Anti-Human CEACAM6 Recombinant Antibody Fab Fragment (NEO-Human 201) IHC, ELISA, FC, WB Humanized antibody
TAB-446LC-F(E) Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-446LC-F(E)) WB, IHC Humanized Fab
TAB-447LC-F(E) Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-447LC-F(E)) WB, IHC Humanized Fab
TAB-448LC-F(E) Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-448LC-F(E)) WB, IHC Humanized Fab
TAB-449LC-F(E) Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (TAB-449LC-F(E)) WB, IHC Humanized Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0650 Hi-Affi™ Rabbit Anti-CEACAM6 Recombinant Antibody (clone DS650AB) WB Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0283-CN-S(P) Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0283-CN-S(P)) ELISA, WB, FC Human scFv
HPAB-0284-CN-S(P) Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0284-CN-S(P)) ELISA, WB, FC Mouse scFv
HPAB-0285-CN-S(P) Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0285-CN-S(P)) ELISA, WB, FC Mouse scFv
HPAB-N0336-YC-S(P) Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-N0336-YC-S(P)) FC, ELISA Human scFv
HPAB-N0045-YC-S(P) Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-N0045-YC-S(P)) FC, WB, IP Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0283-CN-F(E) Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0283-CN-F(E)) ELISA, WB, FC Human Fab
HPAB-0284-CN-F(E) Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0284-CN-F(E)) ELISA, WB, FC Mouse Fab
HPAB-0285-CN-F(E) Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0285-CN-F(E)) ELISA, WB, FC Mouse Fab
HPAB-N0336-YC-F(E) Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-N0336-YC-F(E)) FC, ELISA Humanized Fab
HPAB-N0045-YC-F(E) Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-N0045-YC-F(E)) FC, WB, IP Mouse Fab

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