HLA-A*03:01/Human NP (ILRGSVAHK) MHC Tetramer
CAT#: MHC-YF949
This product is a MHC tetramer of biotinylated peptide/MHC complex composed NP-derived peptide of ILRGSVAHK sequence covering 265-274 and HLA-A*03:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- HLA-A*03:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- NP
- Antigen Species
- Influenza Virus
- Peptide
- ILRGSVAHK
- Range
- 265-274
- Application
- FCM
Target
- Antigen Introduction
- Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
- Alternative Names
- Nucleoprotein; Nucleocapsid protein; Protein N; NP
- Gene ID
- 956531
- UniProt ID
- P03466
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Q&As
-
What is the primary application of the HLA-A03:01 MHC Tetramer?
A: The primary application of the HLA-A03:01 MHC Tetramer is for flow cytometry analysis to identify specific CD8 T-cells that recognize the influenza NP-derived peptide. This permits researchers to study antigen-specific T-cell responses in various immunological contexts.
-
What virus is targeted by the peptide sequence in this MHC Tetramer?
A: The peptide sequence ILRGSVAHK is derived from the Nucleoprotein (NP) of the Influenza Virus, making this reagent particularly useful for virology research focused on influenza.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
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