Anti-CD79b (clone hu2F2.D7)-BMPEO-DMl ADC
CAT#: ADC-204CL
This ADC product is composed of an anti-CD79b antibody (clone hu2F2.D7) conjugated via BMPEO linker to DMl(hu2F2.D7-HC(A118C) Thio-engineered Antibody-BMPEO-DMl). It has demonstrated a response in hematopoietic tumors treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/1889_C4_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside reaction centra and weak to moderate in reaction center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows distinct cytoplasmic positivity in cells of the germinal center corona.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9751/ihc_selected.jpg
Normal Tissue
Figure 4 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/48_C6_1_blue_red_green.jpg
Normal Tissue
Figure 5 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/47_C6_1_blue_red_green.jpg
Normal Tissue
Figure 6 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_3.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007312-CD79B
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Specifications
- Antibody Overview
- hu2F2.D7-HC(A118C) Thio-engineered Antibody
- Clone
- hu2F2.D7
- Antibody Conjugation
- Thio
- Linker
- BMPEO (bis-maleimido-trioxyethylene glycol)
- Drug
- DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);
- Gene ID
- 974
- UniProt ID
- P40259
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Related Signaling Pathways
BCR Signaling Pathway
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Datasheet
MSDS
COA
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- CAT
- Product Name
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| HPAB-J0055-YC-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-J0055-YC-F(E)) | ELISA, FC, Inhib, FuncS | Humanized Fab |
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