Anti-CD79b (clone hu2F2.D7)-BMPEO-DMl ADC (CAT#: ADC-204CL)

• Antibody Overview
• hu2F2.D7-HC(A118C) Thio-engineered Antibody

• Clone
• hu2F2.D7

• Antibody Conjugation
• Thio

• Linker
• BMPEO (bis-maleimido-trioxyethylene glycol)

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);

• Gene ID
• 974

• UniProt ID
• P40259

• ADC-203CL
• Anti-CD79b (clone hu2F2.D7)-SMCC-DM1 ADC

• ADC-205CL
• Anti-CD79b (clone hu2F2.D7)-MC-MMAF ADC

• ADC-206CL
• Anti-CD79b (clone hu2F2.D7)-MCvcPAB-MMAE ADC

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