Anti-CanAg (huC242)-SPP-DM1 ADC (CAT#: ADC-012LCT)

• Antibody Overview
• Humanized Antibody, huC242 (Anti-CanAg)

• Clone
• huC242

• Antibody Isotype
• IgG1

• Linker
• SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)

• Linker Class/Description
• Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

• Drug Class/Description
• Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• The CanAg tumour antigen is a novel glycoform of MUC1.

• Alternative Names
• MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;

• Gene ID
• 4582

• UniProt ID
• P15941

• ADC-008LCT
• Anti-CanAg (huC242)-Mal-dPEG4-NHS-DM1 ADC

• ADC-009LCT
• Anti-CanAg (huC242)-SMCC-DM1 ADC

• ADC-010LCT
• Anti-CanAg (huC242)-Sulfo-SPDB-DM4 ADC

• ADC-011LCT
• Anti-CanAg (huC242)-SPDB-DM4 ADC

• ADC-209LZY
• Anti-CanAg (clone huC242)-SPP-DM1 ADC

• ADC-092LZY
• Anti-CanAg (clone huC242)-SPDB-DM4 ADC

• ADC-212LZY
• Anti-CanAg (clone huC242)-SPP-[3H]DM1 ADC

• ADC-102LZY
• Anti-CanAg (clone huC242)-SMCC-DM1 ADC

• ADC-213LZY
• Anti-CanAg (clone huC242)-SMCC-[3H]DM1 ADC

• ADC-214LZY
• Anti-CanAg (clone huC242)-SPDB-[3H]DM4 ADC

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