Human Anti-ANXA1 scFv-Fc Chimera (VS-0325-FY28)
CAT#: VS-0325-FY28
The anti-ANXA1 scFv-Fc antibody targets ANXA1 (Annexin A1), a protein involved in anti-inflammatory and cell signaling processes. It is formulated with a scFv-Fc construct to improve binding affinity and functional versatility. This antibody is valuable for studying ANXA1's role in immune regulation and its potential as a therapeutic target.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/108_D12_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11272/85_H11_2_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13023/if_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35987/265_B3_1_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_7_5.jpg
Normal Tissue
Figure 6 Esophagus
Squamous epithelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_4_1.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135046-ANXA1
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It specifically binds to an N-terminal region of Annexin A1.
- Species Reactivity
- Human
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Annexin A1; Phospholipase A2 Inhibitory Protein; Chromobindin-9; Calpactin II; Calpactin-2; Annexin-1; ANX1
- Gene ID
- 301
- UniProt ID
- P04083
- Long Name
- Annexin A1
- Cellular Localization
- Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoplasmic vesicle
- Function
- ANXA1, or Annexin A1, is a protein with a multifaceted role in biological processes, prominently featuring in the regulation of inflammatory responses. Its well-established function includes mediating the anti-inflammatory effects of glucocorticoids, where it influences leukocyte trafficking and curbs the production of pro-inflammatory mediators. Beyond its anti-inflammatory actions, ANXA1 participates in various cellular activities, such as cell proliferation, differentiation, and apoptosis, while also contributing to membrane organization and cytoskeletal interactions. Furthermore, ANXA1 plays a role in modulating immune responses, affecting both innate and adaptive immunity, and research has shown interactions with T cell responses. Continuing studies are revealing ANXA1's involvement in a broad spectrum of physiological and pathological processes, including the regulation of metabolic diseases and its potential utility as a tumor marker. Thus, ANXA1 acts as a crucial and versatile modulator across a diverse range of biological pathways.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ANXA1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0923CLV | Human Anti-ANXA1 Recombinant Antibody (TAB-0923CLV) | ELISA | Human IgG |
| TAB-0923CLV-F(E) | Human Anti-ANXA1 Recombinant Antibody; Fab Fragment (TAB-0923CLV-F(E)) | ELISA | Human Fab |
| TAB-0923CLV-S(P) | Human Anti-ANXA1 Recombinant Antibody; scFv Fragment (TAB-0923CLV-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0924CLV | Mouse Anti-ANXA1 Recombinant Antibody (TAB-0924CLV) | FuncS | Mouse IgG2b |
| TAB-0924CLV-F(E) | Mouse Anti-ANXA1 Recombinant Antibody; Fab Fragment (TAB-0924CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0924CLV-S(P) | Mouse Anti-ANXA1 Recombinant Antibody; scFv Fragment (TAB-0924CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0633MZ | Mouse Anti-ANXA1 Recombinant Antibody (clone CBLS-103) | ELISA | Mouse IgG2a |
| FAMAB-1010CQ | Mouse Anti-ANXA1 Recombinant Antibody (clone SAIC-13C-5G10) | Immuno-MRM, ELISA | Mouse IgG1 |
| ZG-0033J | Mouse Anti-ANXA1 Recombinant Antibody (ZG-0033J) | IHC-P, IF | Mouse IgG |
| ZG-0034J | Mouse Anti-ANXA1 Recombinant Antibody (ZG-0034J) | IHC-P, IF | Mouse IgG |
| VS4-WK31 | Mouse Anti-ANXA1 Recombinant Antibody (VS4-WK31) | ELISA, IHC | Mouse IgG1, Kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0182 | Hi-Affi™ Rabbit Anti-ANXA1 Recombinant Antibody (clone DS182AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1973 | PE-B7/Human ANXA1 (KPAFFAEKL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0914-WJ-S(P) | Mouse Anti-ANXA1 Recombinant Antibody; scFv Fragment (HPAB-0914-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0914-WJ-F(E) | Mouse Anti-ANXA1 Recombinant Antibody; Fab Fragment (HPAB-0914-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY116 | Anti-ANXA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY406 | Anti-Mouse ANXA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY405 | Anti-Human ANXA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY407 | Anti-Rat ANXA1 Immunohistochemistry Kit | IHC |
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