Human Anti-ANXA1 scFv-Fc Chimera (VS-0325-FY28) (CAT#: VS-0325-FY28)
The anti-ANXA1 scFv-Fc antibody targets ANXA1 (Annexin A1), a protein involved in anti-inflammatory and cell signaling processes. It is formulated with a scFv-Fc construct to improve binding affinity and functional versatility. This antibody is valuable for studying ANXA1's role in immune regulation and its potential as a therapeutic target.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/108_D12_1_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/108_D12_1_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11272/85_H11_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11272/85_H11_2_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13023/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13023/if_selected.jpg
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35987/265_B3_1_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35987/265_B3_1_selected.jpg
Figure 5 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_7_5.jpg
Figure 6 Esophagus
(Squamous epithelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_4_1.jpg
(Squamous epithelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_4_1.jpg
Figure 7 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_A_8_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_A_8_5.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135046-ANXA1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135046-ANXA1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It specifically binds to an N-terminal region of Annexin A1.
- Species Reactivity
- Human
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Annexin A1; Phospholipase A2 Inhibitory Protein; Chromobindin-9; Calpactin II; Calpactin-2; Annexin-1; ANX1
- Gene ID
- 301
- UniProt ID
- P04083
- Long Name
- Annexin A1
- Cellular Localization
- Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoplasmic vesicle
- Function
- ANXA1, or Annexin A1, is a protein with a multifaceted role in biological processes, prominently featuring in the regulation of inflammatory responses. Its well-established function includes mediating the anti-inflammatory effects of glucocorticoids, where it influences leukocyte trafficking and curbs the production of pro-inflammatory mediators. Beyond its anti-inflammatory actions, ANXA1 participates in various cellular activities, such as cell proliferation, differentiation, and apoptosis, while also contributing to membrane organization and cytoskeletal interactions. Furthermore, ANXA1 plays a role in modulating immune responses, affecting both innate and adaptive immunity, and research has shown interactions with T cell responses. Continuing studies are revealing ANXA1's involvement in a broad spectrum of physiological and pathological processes, including the regulation of metabolic diseases and its potential utility as a tumor marker. Thus, ANXA1 acts as a crucial and versatile modulator across a diverse range of biological pathways.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0923CLV | Human Anti-ANXA1 Recombinant Antibody (TAB-0923CLV) | ELISA | Human IgG |
| TAB-0923CLV-F(E) | Human Anti-ANXA1 Recombinant Antibody; Fab Fragment (TAB-0923CLV-F(E)) | ELISA | Human Fab |
| TAB-0923CLV-S(P) | Human Anti-ANXA1 Recombinant Antibody; scFv Fragment (TAB-0923CLV-S(P)) | ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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