Human Anti-APCS scFv-Fc Chimera (VS-0425-FY182)
CAT#: VS-0425-FY182
The anti-APCS scFv-FC is a monoclonal antibody designed to target the Amyloid Precursor Protein Cleaving Enzyme (APCS). The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to APCS with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of neurobiology and amyloid-related diseases.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows positivity in plasma.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human soft tissue
Immunohistochemical staining of human soft tissue shows positivity in plasma.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7817/ihc_selected.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (RH-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132703-APCS
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Specifications
- Immunogen
- Purified human SAP.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human APCS
- Species Reactivity
- Human
- Applications
- Western Blot, ELISA, Immunohistochemistry
- Related Disease
- Systemic amyloidosis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:500
ELISA: 1:100-1:10000
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Amyloid P Component, Serum; 9.5S Alpha-1-Glycoprotein; Pentraxin-Related; Pentraxin-2; PTX2; SAP
- Gene ID
- 325
- UniProt ID
- P02743
- Long Name
- Amyloid P Component, Serum
- Cellular Localization
- Secreted
- Post Translation Modifications
- N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP).
Monosialo-SAP as well as asioalo-SAP are also detected.
Glycosylation at Asn51
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect SAMP_HUMAN (560)
Glycosylation from GlyGen 2 sites, 16 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001630.1
- Function
- Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
May also function as a calcium-dependent lectin.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "APCS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2232z | Mouse Anti-APCS Recombinant Antibody (clone 38A6) | WB, ELISA, FC, ICC, IF, IHC, IP | Mouse IgG1 |
| MOB-1834MZ | Mouse Anti-APCS Recombinant Antibody (clone IZC392-06) | ELISA, WB, sELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-022CQ | Mouse Anti-APCS Recombinant Antibody (clone CBL362) | Block | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0200 | Hi-Affi™ Rabbit Anti-APCS Recombinant Antibody (clone DS200AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-019ML | Anti-Human APCS Recombinant Antibody (TAB-019ML) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-019ML | Afuco™ Anti-APCS ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-019ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY441 | Anti-APCS Immunohistochemistry Kit | IHC |
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