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    Human Anti-APLP2 scFv-Fc Chimera (VS-0625-FY1) (CAT#: VS-0625-FY1)

    This is a monoclonal antibody clone developed for the specific targeting of human Amyloid Precursor-Like Protein 2 (APLP2). This antibody is a valuable tool for researchers investigating the role of APLP2 in various biological processes and disease states. The anti-APLP2 scFv-Fc is a sophisticated bio-engineered molecule leveraging the precision targeting of an scFv with the stability and immune-modulating capabilities of an Fc domain, offering a powerful tool for both research and potential therapeutic development related to APLP2.

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    • Purity:

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    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/39319/if_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/39319/82033_B_8_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/39319/82033_A_8_3.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/39319/82033_A_8_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/39319/82033_A_5_6.jpg
    Figure 6 Heart muscle
    Figure 6 Heart muscle
    (Cardiomyocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/39319/82033_B_5_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/39319/82033_A_7_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000084234-APLP2

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human APLP2
    • Species Reactivity
    • Human
    • Applications
    • Western Blot
    • Related Disease
    • Alzheimer's disease

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The optimal dilution concentration is determined by the experiment.

    Target

    • Alternative Names
    • Amyloid Beta Precursor Like Protein 2; Amyloid Beta (A4) Precursor-Like Protein 2; CDEI Box-Binding Protein; APLP-2; APPL2; CDEBP
    • Long Name
    • Amyloid Beta Precursor Like Protein 2
    • Sequence Similarities
    • Belongs to the APP family.
    • Cellular Localization
    • Cell membrane, Membrane, Nucleus
    • Post Translation Modifications
    • The BPTI/Kunitz inhibitor domain is O-glycosylated.
      Glycosylation at Thr380, Ser381, Asn541, Thr367, Thr371, and Thr658
      Ubiquitination at Lys744 and Lys756
      Modification sites at PhosphoSitePlus
      Glycosylation from Gly
      Glycosylation from GlyGen 10 sites, 4 N-linked glycans (1 site), 2 O-linked glycans (8 sites)
    • Function
    • May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    MOR-0203 Hi-Affi™ Rabbit Anti-APLP2 Recombinant Antibody (clone DS203AB) IHC-P, WB Rabbit IgG

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