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    Human Anti-BCAM (clone C7) scFv-Fc Chimera (CAT#: VS-0325-FY144)

    This product is a human single-chain variable fragment-Fc (scFv-Fc) antibody construct targeting CD239. It is based on the C7 phage clone. The scFv portion, derived from the variable regions of the heavy and light chains of the C7 antibody, is linked and then fused to the Fc portion of human IgG1. This construct is designed for potential therapeutic applications, particularly as a component of antibody-drug conjugates (ADCs). The C7-Fc antibody binds to CD239-expressing cells, and when conjugated with a cytotoxic drug like a fragment of diphtheria toxin (fDT), it can selectively kill these cells. The text shows that the C7-Fc antibody alone does not influence cellular functions, highlighting the importance of the drug conjugate for its anticancer activity.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoli fibrillar center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5654/if_selected.jpg
    Figure 2 IF staining of human cell line U-2 OS
    Figure 2 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5654/607_G4_1_blue_red_green.jpg
    Figure 3 IF staining of human cell line U-251 MG
    Figure 3 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli fibrillar center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5654/604_G4_1_blue_red_green.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5654/55689_B_9_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5654/55689_A_9_3.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Bowman's capsule
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Collecting ducts
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Distal tubules
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5654/55689_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Leydig cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5654/55689_A_6_6.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (BEWO, HaCaT, SK-BR-3, T-47d, U-2 OS)
    Figure 8 RNA cell line category: Cell line enhanced (BEWO, HaCaT, SK-BR-3, T-47d, U-2 OS)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187244-BCAM
    Figure 8 RNA cell line category: Cell line enhanced (BEWO, HaCaT, SK-BR-3, T-47d, U-2 OS)
    Figure 8 RNA cell line category: Cell line enhanced (BEWO, HaCaT, SK-BR-3, T-47d, U-2 OS)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187244-BCAM

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human BCAM
    • Species Reactivity
    • Human
    • Clone
    • C7
    • Applications
    • ADC
    • Related Disease
    • Cancer

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Target

    • Alternative Names
    • Basal Cell Adhesion Molecule (Lutheran Blood Group); Basal Cell Adhesion Molecule (Lu And Au Blood Groups); B-CAM Cell Surface Glycoprotein; Auberger B Antigen; F8/G253 Antigen; MSK19; LU; Lutheran Blood Group (Auberger B Antigen Included); Lutheran Blood Group Variant LUGA
    • Long Name
    • Basal Cell Adhesion Molecule (Lutheran Blood Group)
    • Cellular Localization
    • Membrane
    • Post Translation Modifications
    • Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.
      Glycosylation at Asn321, Asn377, Asn383, Asn419, and Asn439
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyConnect BCAM_HUMAN (1026)
      Glycosylation from GlyGen 7 sites, 9 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)
    • Function
    • May mediate intracellular signaling.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone C7"

    See other products for "BCAM"

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    CAT Product Name Application Type
    MOB-1207z Mouse Anti-BCAM Recombinant Antibody (clone 38G1) WB, IP, IF, ELISA Mouse IgG2b, κ
    MOB-2125MZ Mouse Anti-BCAM Recombinant Antibody (clone NN0208-2N40) WB Mouse IgG2
    FAMAB-0449WJ Human Anti-BCAM Recombinant Antibody (clone A1) ELISA, WB, FC Human IgG
    FAMAB-0450WJ Human Anti-BCAM Recombinant Antibody (clone A4) ELISA, WB, FC Human IgG
    FAMAB-0451WJ Human Anti-BCAM Recombinant Antibody (clone B8) ELISA, WB, FC Human IgG

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