Recombinant Human Anti-CASP8 Soluble TCR (121) (KIH) (CAT#: VS-0622-YF5432)
Human TCR (121) recognizes CASP8 peptide (FPSDSWCYF) in the context of HLA-B*3503. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/69_H9_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/69_H9_2_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6191/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6191/if_selected.jpg
Figure 3 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2047/5614_A_8_2_selected.jpg
(Immunohistochemical staining of human duodenum shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2047/5614_A_8_2_selected.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/30722_A_6_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/30722_A_6_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/30722_A_9_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/30722_A_9_8.jpg
Figure 6 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/30722_A_7_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1302/30722_A_7_5.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000064012-CASP8
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000064012-CASP8
Specifications
- Host Species
- Human
- Target
- CASP8
- Species Reactivity
- Human
- Epitope
- FPSDSWCYF
- MHC
- HLA-B*3503
- Clone
- 121
- Type
- Soluble TCR (KIH)
- Related Disease
- Head-and-neck cancer
- TCR Expression Strategy
- KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).
Target
- Alternative Names
- CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase 8
- Gene ID
- 841
- UniProt ID
- Q14790
Related Resources
TNF Signaling Pathway
Downloads
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1464z | Mouse Anti-CASP8 Recombinant Antibody (clone 24C10) | WB, ELISA, FC, IHC | Mouse IgG1 |
| ZG-0072J | Mouse Anti-CASP8 Recombinant Antibody (clone 2G12) | WB, IF, ICC, IHC-P | Mouse IgG |
| ZG-0833F | Mouse Anti-CASP8 Recombinant Antibody (clone FLICE 1 1-37) | WB | Mouse IgG |
| ZG-0834F | Mouse Anti-CASP8 Recombinant Antibody (clone FLICE 3) | WB | Mouse IgG |
| VS7-HM297 | Mouse Anti-CASP8 Recombinant Antibody (clone CBL097HM) | WB, IHC-p, IF, FCM, ELISA | Mouse IgG |
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