Human Anti-CCR2 (clone MLN1202) scFv-Fc Chimera (CAT#: VS-0425-FY74)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human CCR2

• Species Reactivity
• Human

• Clone
• MLN1202

• Applications
• Immunoassay

• Related Disease
• Idiopathic Anterior Uveitis and Cd3zeta Deficiency

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• C-C Motif Chemokine Receptor 2; Monocyte Chemoattractant Protein 1 Receptor; Chemokine (C-C Motif) Receptor 2; CC-CKR-2; MCP-1-R; CMKBR2; CCR-2; Monocyte Chemotactic Protein 1 Receptor; C-C Chemokine Receptor Type 2; MCP-1 Receptor

• Gene ID
• 729230

• UniProt ID
• P41597

• Long Name
• C-C Motif Chemokine Receptor 2

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• N-glycosylated.
  Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form.
  Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
  Glycosylation at Asn14
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site

• Protein Refseq
• NP_001116513.2; NP_001116868.1

• Function
• Key functional receptor for CCL2 but can also bind CCL7, and CCL12.
  Also transduces signaling mediated by CCL13.
  Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion.
  Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B.
  Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation.
  Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R.
  Plays an important role in mediating peripheral nerve injury-induced neuropathic pain.
  Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
  Mediates the recruitment of macrophages and monocytes to the injury site following brain injury.

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