Human Anti-CD52 (clone HI52) scFv-Fc Chimera (CAT#: VS-0125-FY57)
Anti-CD52 scFv-Fc is a recombinant protein composed of a single-chain antibody (scFv) and an Fc fragment, featuring high stability and affinity. Its humanized or fully human characteristics help reduce immunogenicity. This product is typically produced using cell engineering technology in cell culture, ensuring efficient expression and purification. It is primarily used for research, clinical trials, and potential therapeutic applications, providing new directions for tumor immunotherapy.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Group enriched (Daudi, REH, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169442-CD52
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169442-CD52
Figure 1 RNA cell line category: Group enriched (Daudi, REH, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169442-CD52
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169442-CD52
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- HI52
- Applications
- Inhibition, Antibody-dependent cellular cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Anti-CD52 scFv-Fc is a recombinant antibody specifically targeting the CD52 protein, which is mainly expressed on certain immune cells and other cell types. This antibody binds to CD52-positive cells, marking them for immune-mediated cell killing. Its potential functions include the treatment of chronic lymphocytic leukemia and other types of leukemia and lymphoma. Furthermore, it may play a role in transplant rejection and autoimmune diseases. The Fc region of anti-CD52 scFv-Fc can activate the complement system, mediating antibody-dependent cell cytotoxicity (ADCC), thereby enhancing the overall immune response. By achieving both antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, anti-CD52 scFv-Fc has the potential to effectively eliminate CD52-positive cells.
Target
- Alternative Names
- CD52 Molecule; Human Epididymis-Specific Protein 5; CD52 Antigen (CAMPATH-1 Antigen); Epididymal Secretory Protein E5; Cambridge Pathology 1 Antigen; CDW52; He5
- Gene ID
- 1043
- UniProt ID
- P31358
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn27 and Asn40
Glycosylation from GlyGen 3 sites
- Protein Refseq
- NP_001794.2
- Function
- May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Hexamer Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1223z | Mouse Anti-CD52 Recombinant Antibody (clone 20C9) | WB, ELISA, FC, IHC, FuncS | Mouse IgG1, κ |
| PABC-021 | Rat Anti-CD52 Recombinant Antibody (clone CAMPATH-1G) | WB, IHC, IF, FuncS | Rat IgG2b |
| HPAB-0940WJ | Mouse Anti-CD52 Recombinant Antibody (HPAB-0940WJ) | ELISA, FC | Mouse IgG3 |
| HPAB-0941WJ | Mouse Anti-CD52 Recombinant Antibody (HPAB-0941WJ) | ELISA, FC | Mouse IgG3 |
| HPAB-0942WJ | Mouse Anti-CD52 Recombinant Antibody (HPAB-0942WJ) | ELISA, FC | Mouse IgG3 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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