Human Anti-CD86 (clone Hu3D1) scFv-Fc Chimera
CAT#: VS-0425-FY10
The anti-CD86 scFv-Fc is a novel therapeutic antibody designed to target the CD86 molecule, which plays a crucial role in immune modulation. This engineered protein combines the single-chain variable fragment (scFv) specific for CD86 with the Fc region of an antibody, enhancing its stability and half-life in circulation. By binding to CD86, the scFv-Fc can effectively interfere with the activation of T cells, making it a potential candidate for treating autoimmune diseases and promoting tolerance in transplant scenarios. Its unique design provides advantages over traditional antibodies, such as improved specificity and reduced immunogenicity. Preclinical studies have shown promising results in modulating immune responses, indicating its potential for clinical applications. Overall, the anti-CD86 scFv-Fc represents a significant advancement in targeted immunotherapy, with the ability to fine-tune the immune system's activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26802/1962_A12_6_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_B_8_5.jpg
Normal Tissue
Figure 3 Lung
Macrophages Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_1_4.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_8_3.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000114013-CD86
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CD86
- Species Reactivity
- Human
- Clone
- Hu3D1
- Applications
- Inhibition
- Related Disease
- Autoimmune disease, Transplant rejection, Inflammatory disorders, Infectious disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- CD86 Molecule; CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen); CTLA-4 Counter-Receptor B7.2; CD28LG2; FUN-1; BU63; B70; B-Lymphocyte Activation Antigen B7-2
- Gene ID
- 942
- UniProt ID
- P42081
- Long Name
- CD86 Molecule
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Glycosylation at Asn135, Asn33, Asn146, Asn47, Asn154, Asn177, Asn192, and Asn213
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites
- Protein Refseq
- NP_001193853.2; NP_001193854.2; NP_008820.4; NP_787058.5; NP_795711.2
- Function
- May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.
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Related Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Name
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