Human Anti-CGB5 scFv-Fc Chimera (VS-0125-FY103)
CAT#: VS-0125-FY103
The product is a scFv-Fc antibody targeting human chorionic gonadotropin (hCG). hCG is a hormone secreted by the placenta and is commonly used for pregnancy testing. Antibodies targeting hCG can be widely applied in clinical pregnancy detection tools. The scFv-Fc molecule is formed by the combination of a single-chain variable fragment (scFv) with an Fc fragment (typically derived from IgG), providing higher stability and enhanced effects. This scFv-Fc antibody can specifically recognize its target antigens, such as EGFR and hCG, making it suitable for research, diagnostics, and potential therapeutic applications. This opens up new ideas and directions for future antibody development and application.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/537_C10_3_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/540_C10_1_blue_red_green.jpg
Normal Tissue
Figure 4 Placenta
Trophoblastic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38934/101364_A_2_7.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (BEWO, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000189052-CGB5
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Applications
- Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Chorionic Gonadotropin Beta Subunit 5; Chorionic Gonadotropin, Beta Polypeptide 5; CGB; Chorionic Gonadotropin Beta 5 Subunit; Chorionic Gonadotropin Chain Beta; Choriogonadotropin Subunit Beta
- Gene ID
- 93659
- UniProt ID
- P0DN86
- Sequence Similarities
- Belongs to the glycoprotein hormones subunit beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CGB3_HUMAN (88, 91)
Glycosylation from GlyGen 9 sites, 28 N-linked glycans (3 sites), 15 O-linked glycans (5 sites)
- Protein Refseq
- NP_149032.1
- Function
- Beta subunit of the human chorionic gonadotropin (hCG).
hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated.
The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH).
The beta subunits are distinct in each of the hormones and confer receptor and biological specificity.
Has an essential role in pregnancy and maternal adaptation.
Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CGB5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1302z | Mouse Anti-CGB5 Recombinant Antibody (clone 22C1) | IHC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-108 | Recombinant Anti-Human CGB5 VHH Single Domain Antibody | IHC, FC, CA, FuncS | Llama VHH |
| PNBL-087 | Recombinant Anti-HCG VHH Single Domain Antibody (PNBL-087) | ELISA | Llama VHH |
| PNBL-093 | Recombinant Anti-hCG VHH Single Domain Antibody (PNBL-093) | WB, ELISA, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0679 | Hi-Affi™ Rabbit Anti-CGB5 Recombinant Antibody (clone YC021) | WB | Rabbit IgG |
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