Human Anti-CGB5 scFv-Fc Chimera (VS-0125-FY103) (CAT#: VS-0125-FY103)
The product is a scFv-Fc antibody targeting human chorionic gonadotropin (hCG). hCG is a hormone secreted by the placenta and is commonly used for pregnancy testing. Antibodies targeting hCG can be widely applied in clinical pregnancy detection tools. The scFv-Fc molecule is formed by the combination of a single-chain variable fragment (scFv) with an Fc fragment (typically derived from IgG), providing higher stability and enhanced effects. This scFv-Fc antibody can specifically recognize its target antigens, such as EGFR and hCG, making it suitable for research, diagnostics, and potential therapeutic applications. This opens up new ideas and directions for future antibody development and application.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/537_C10_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/537_C10_3_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/540_C10_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/540_C10_1_blue_red_green.jpg
Figure 4 Placenta
(Trophoblastic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38934/101364_A_2_7.jpg
(Trophoblastic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38934/101364_A_2_7.jpg
Figure 5 RNA cell line category: Group enriched (BEWO, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000189052-CGB5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000189052-CGB5
Figure 5 RNA cell line category: Group enriched (BEWO, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000189052-CGB5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000189052-CGB5
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Applications
- Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Chorionic Gonadotropin Beta Subunit 5; Chorionic Gonadotropin, Beta Polypeptide 5; CGB; Chorionic Gonadotropin Beta 5 Subunit; Chorionic Gonadotropin Chain Beta; Choriogonadotropin Subunit Beta
- Gene ID
- 93659
- UniProt ID
- P0DN86
- Sequence Similarities
- Belongs to the glycoprotein hormones subunit beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CGB3_HUMAN (88, 91)
Glycosylation from GlyGen 9 sites, 28 N-linked glycans (3 sites), 15 O-linked glycans (5 sites)
- Protein Refseq
- NP_149032.1
- Function
- Beta subunit of the human chorionic gonadotropin (hCG).
hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated.
The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH).
The beta subunits are distinct in each of the hormones and confer receptor and biological specificity.
Has an essential role in pregnancy and maternal adaptation.
Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1302z | Mouse Anti-CGB5 Recombinant Antibody (clone 22C1) | IHC, WB | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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