Human Anti-CRP scFv-Fc Chimera (VS-0125-FY49)
CAT#: VS-0125-FY49
This scFv-Fc fusion protein designed to specifically bind to C-reactive protein (CRP), which plays an important role in inflammatory responses. The scFv part consists of single-chain antibody fragments capable of effectively recognizing and binding to CRP, thereby enhancing the affinity of the antibody. Through this specific binding, the fusion protein assists in monitoring and assessing inflammatory states, improving the accuracy of disease diagnosis. In the future, this engineered antibody fragment may provide new insights and methods for the treatment and management of inflammation-related diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27367/1842_C4_62_selected.jpg
Subcellular Location
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27367/ihc_selected.jpg
Subcellular Location
Figure 3 IHC staining of human blood vessel
Immunohistochemical staining of human blood vessel shows distinct positivity of plasma.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5036/ihc_selected.jpg
Normal Tissue
Figure 4 Immunofluorescent staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27367/395_F9_1_red_green.jpg
Normal Tissue
Figure 5 Immunofluorescent staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27367/399_F9_1_red_green.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5036/14071_A_8_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (EFO-21, HDLM-2, U-2 OS, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132693-CRP
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Inflammation
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- C-Reactive Protein; C-Reactive Protein, Pentraxin-Related; Pentraxin 1; PTX1
- Gene ID
- 1401
- UniProt ID
- P02741
- Cellular Localization
- Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_000558.2; NP_001315986.1
- Function
- Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CRP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1013 | Mouse Anti-CRP Recombinant Antibody (clone YC027); Fab Fragment | ELISA, LMNX, LFIA | Mouse Fab |
| HPAB-0213-FY-F(E) | Mouse Anti-CRP Recombinant Antibody Fab Fragment (HPAB-0213-FY-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0214-FY-F(E) | Mouse Anti-CRP Recombinant Antibody Fab Fragment (HPAB-0214-FY-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-M0039-YC-F(E) | Mouse Anti-CRP Recombinant Antibody (clone P24); Fab Fragment | ELISA | Mouse Fab |
| HPAB-M0040-YC-F(E) | Mouse Anti-CRP Recombinant Antibody (clone P03); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0965MZ | Recombinant Mouse Anti-Human CRP Antibody (clone 74G5) | ELISA | Mouse antibody |
| HPAB-0213-FY | Mouse Anti-CRP Recombinant Antibody (HPAB-0213-FY) | ELISA, WB | Mouse IgG |
| HPAB-0214-FY | Mouse Anti-CRP Recombinant Antibody (HPAB-0214-FY) | ELISA, WB | Mouse IgG |
| VS3-WK63 | Mouse Anti-CRP Recombinant Antibody (clone E8-G1) | WB, ELISA | Mouse IgG1 |
| VS12-QX3 | Rabbit Anti-CRP Antibody (VS12-QX3) | IA, Diagnostics, RI, IP, IE, ID, Latex agglutination | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0646MZ | Chicken Anti-Human C Reactive Protein (hCRP) Polyclonal IgY | N/A | Chicken antibody |
| BRD-0647MZ | Chicken Anti-Human C Reactive Protein (hCRP) complete IgY egg yolk Polyclonal IgY | N/A | Chicken antibody |
| BRD-0827MZ | Chicken Anti-CRP Polyclonal IgY | ELISA, ICC, WB | Chicken antibody |
| BRD-0913MZ | Chicken Anti-CRP Polyclonal IgY | ELISA, WB | Chicken antibody |
| BRD-1125MZ | Chicken Anti-Human CRP Polyclonal IgY | Indirect ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0810 | Hi-Affi™ Rabbit Anti-CRP Recombinant Antibody (clone DS810AB) | WB | Rabbit IgG |
| MOR-4559 | Hi-Affi™ Rabbit Anti-CRP Recombinant Antibody (clone TH69DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0213-FY-S(P) | Mouse Anti-CRP Recombinant Antibody scFv Fragment (HPAB-0213-FY-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0214-FY-S(P) | Mouse Anti-CRP Recombinant Antibody scFv Fragment (HPAB-0214-FY-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-M0039-YC-S(P) | Mouse Anti-CRP Recombinant Antibody (clone P24); scFv Fragment | ELISA | Mouse scFv |
| HPAB-M0040-YC-S(P) | Mouse Anti-CRP Recombinant Antibody (clone P03); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC690 | AbPlus™ Anti-CRP Magnetic Beads (VS-0724-YC690) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY548 | Anti-CRP Immunohistochemistry Kit | IHC | |
| VS-0525-XY1678 | Anti-Human CRP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC75 | Recombinant Anti-CRP Eliminating Antibody, pH-Sensitive (VS-0625-YC75) | Antigen-Sweeping In Vivo. | Mouse IgG |
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