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    Human Anti-CTLA4 (clone JMW-3B3) scFv-Fc Chimera

    CAT#: VS-0325-FY63

    The anti-CTLA4 scFv-Fc antibody is a specialized therapeutical agent designed to inhibit the CTLA-4 protein, which plays a critical role in downregulating immune responses. This antibody enhances T-cell activation and proliferation, making it a promising tool in cancer immunotherapy. The clone JMW-3B3, may bind sCTLA-4 with high affinity.

    Gene Expression
    ❮
    Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
    ❯

    Specifications

    • Immunogen
    • The immunogen used to generate JMW-3B3 is a peptide fragment of sCTLA-4 with the amino acid sequence AKEKKPSYNRGLCENAPNRARM.
    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • JMW-3B3 was raised against the unique C-terminal region of soluble CTLA-4 it does not cross-react the extracellular CTLA-4 domain.
    • Species Reactivity
    • Human
    • Clone
    • JMW-3B3
    • Applications
    • ELISA
    • Related Disease
    • Cancer

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Target

    • Alternative Names
    • Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; CTLA-4; CD152; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Antigen 4; Cytotoxic T-Lymphocyte Protein 4
    • Long Name
    • Cytotoxic T-Lymphocyte Associated Protein 4
    • Cellular Localization
    • Cell membrane
    • Post Translation Modifications
    • N-glycosylation is important for dimerization.
      Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
      Glycosylation at Asn113 and Asn145
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 2 sites
    • Function
    • Inhibitory receptor acting as a major negative regulator of T-cell responses.
      The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
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    Related Diseases

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    Downloadable Resources

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    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0325-FY63.pdf

    MSDS

    MSDS - VS-0325-FY63.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

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