Human Anti-CTLA4 (clone JMW-3B3) scFv-Fc Chimera (CAT#: VS-0325-FY63)
The anti-CTLA4 scFv-Fc antibody is a specialized therapeutical agent designed to inhibit the CTLA-4 protein, which plays a critical role in downregulating immune responses. This antibody enhances T-cell activation and proliferation, making it a promising tool in cancer immunotherapy. The clone JMW-3B3, may bind sCTLA-4 with high affinity.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Specifications
- Immunogen
- The immunogen used to generate JMW-3B3 is a peptide fragment of sCTLA-4 with the amino acid sequence AKEKKPSYNRGLCENAPNRARM.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- JMW-3B3 was raised against the unique C-terminal region of soluble CTLA-4 it does not cross-react the extracellular CTLA-4 domain.
- Species Reactivity
- Human
- Clone
- JMW-3B3
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; CTLA-4; CD152; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Antigen 4; Cytotoxic T-Lymphocyte Protein 4
- Gene ID
- 1493
- UniProt ID
- P16410
- Long Name
- Cytotoxic T-Lymphocyte Associated Protein 4
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylation is important for dimerization.
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Glycosylation at Asn113 and Asn145
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_001032720.1
- Function
- Inhibitory receptor acting as a major negative regulator of T-cell responses.
The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067 | Anti-Human CTLA4 Recombinant Antibody (TAB-067) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-206 | Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG2 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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