Human Anti-CXCR5 (clone 40C01-VH1-Vk3) scFv-Fc Chimera
CAT#: VS-0425-FY18
This scFv-Fc antibody, designed to target CXCR5, displays cross-reactivity with both human and cynomolgus monkey receptors. By effectively neutralizing CXCR5 signaling and inhibiting CXCL13-driven chemotaxis, it presents a compelling therapeutic candidate for conditions where CXCR5-mediated cell migration plays a significant pathogenic role, such as autoimmune/inflammatory disorders and certain cancers.
Gene Expression
Normal Tissue
Figure 1 Skin
Fibroblasts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_B_8_1.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_8.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Fibroblasts Staining: Low Intensity: Weak Goblet cells Staining: Medium Intensity: Moderate Quantity:>75% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160683-CXCR5
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Specifications
- Immunogen
- CXCR5 protein as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It specifically targets human CXCR5. It also exhibits cross-reactivity with cynomolgus monkey (Macaca fascicularis) CXCR5.
- Species Reactivity
- Human, Monkey
- Clone
- 40C01-VH1-Vk3
- Applications
- Flow Cytometry, Inhibition, ADCC
- Related Disease
- Burkitt Lymphoma and Lymphoma
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- C-X-C Motif Chemokine Receptor 5; Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C Motif) Receptor 5); Burkitt Lymphoma Receptor 1, GTP-Binding Protein; Chemokine (C-X-C Motif) Receptor 5; Monocyte-Derived Receptor 15; CXC-R5; CXCR-5; MDR-15
- Gene ID
- 643
- UniProt ID
- P32302
- Long Name
- C-X-C Motif Chemokine Receptor 5
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn28 and Asn196
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_054225616.1; NP_001707.1; NP_116743.1
- Function
- Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC).
Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.
May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- CAT
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0109-LSX-S(P) | Mouse Anti-CXCR5 Recombinant Antibody (clone 2C9); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0110-LSX-S(P) | Human Anti-CXCR5 Recombinant Antibody (clone H4BL2); scFv Fragment | ELISA, WB | Humanized scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0109-LSX-F(E) | Mouse Anti-CXCR5 Recombinant Antibody (clone 2C9); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0110-LSX-F(E) | Human Anti-CXCR5 Recombinant Antibody (clone H4BL2); Fab Fragment | ELISA, WB | Humanized Fab |
| HPAB-0111-LSX-F(E) | Mouse Anti-CXCR5 Recombinant Antibody; Fab Fragment (HPAB-0111-LSX-F(E)) | RIA, FC, WB | Mouse Fab |
| HPAB-0112-LSX-F(E) | Human Anti-CXCR5 Recombinant Antibody; Fab Fragment (HPAB-0112-LSX-F(E)) | RIA, FC, WB | Chimeric (mouse/human) Fab |
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