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    Human Anti-CXCR5 (clone 40C01-VH1-Vk3) scFv-Fc Chimera (CAT#: VS-0425-FY18)

    This scFv-Fc antibody, designed to target CXCR5, displays cross-reactivity with both human and cynomolgus monkey receptors. By effectively neutralizing CXCR5 signaling and inhibiting CXCL13-driven chemotaxis, it presents a compelling therapeutic candidate for conditions where CXCR5-mediated cell migration plays a significant pathogenic role, such as autoimmune/inflammatory disorders and certain cancers.

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    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Skin
    Figure 1 Skin
    (Fibroblasts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_B_8_1.jpg
    Figure 2 Lymph node
    Figure 2 Lymph node
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_8.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Fibroblasts Staining: Low Intensity: Weak Goblet cells Staining: Medium Intensity: Moderate Quantity:>75% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_7_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_8_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/42432/123487_A_5_6.jpg
    RNA Expression
    Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
    Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160683-CXCR5

    Specifications

    • Immunogen
    • CXCR5 protein as an immunogen.
    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • It specifically targets human CXCR5. It also exhibits cross-reactivity with cynomolgus monkey (Macaca fascicularis) CXCR5.
    • Species Reactivity
    • Human, Monkey
    • Clone
    • 40C01-VH1-Vk3
    • Applications
    • Flow Cytometry, Inhibition, ADCC
    • Related Disease
    • Burkitt Lymphoma and Lymphoma

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The optimal dilution concentration is determined by the experiment.

    Target

    • Alternative Names
    • C-X-C Motif Chemokine Receptor 5; Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C Motif) Receptor 5); Burkitt Lymphoma Receptor 1, GTP-Binding Protein; Chemokine (C-X-C Motif) Receptor 5; Monocyte-Derived Receptor 15; CXC-R5; CXCR-5; MDR-15
    • Long Name
    • C-X-C Motif Chemokine Receptor 5
    • Sequence Similarities
    • Belongs to the G-protein coupled receptor 1 family.
    • Cellular Localization
    • Cell membrane
    • Post Translation Modifications
    • Glycosylation at Asn28 and Asn196
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 3 sites
    • Function
    • Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC).
      Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.
      May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    CAT Product Name Application Type
    TAB-156MZ Human Anti-CXCR5 Recombinant Antibody (TAB-156MZ) FC Human IgG1
    TAB-157MZ Human Anti-CXCR5 Recombinant Antibody (TAB-157MZ) FC Human IgG1
    TAB-158MZ Human Anti-CXCR5 Recombinant Antibody (TAB-158MZ) FC Human IgG1
    TAB-159MZ Human Anti-CXCR5 Recombinant Antibody (TAB-159MZ) FC Human IgG1
    TAB-160MZ Human Anti-CXCR5 Recombinant Antibody (TAB-160MZ) FC Human IgG1

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