Human Anti-DNA (clone 71F12) scFv-Fc Chimera (CAT#: VS-0325-FY165)
This is a cell-internalizable, chimeric anti-DNA antibody in scFv-Fc format, designed to mimic the activity of autoantibodies found in systemic lupus erythematosus (SLE). It can enter live cells and trigger the production of the pro-inflammatory cytokines IL-8 and TNF-α through an Fc-dependent pathway. This makes it a valuable research tool for investigating the mechanisms of anti-DNA antibody-induced inflammation and the role of cytosolic Fc receptors in immune signaling.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human DNA
- Species Reactivity
- Human
- Clone
- 71F12
- Applications
- ELISA, Immunofluorescence
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunofluorescence: 2 μg/mL
ELISA: 5 μg/mL
Target
- Alternative Names
- DNA (Cytosine-5)-methyltransferase 1; DNA
- Long Name
- DNA (Cytosine-5)-methyltransferase 1
- Function
- Human DNA is the genetic material that carries the hereditary information in humans, composed of nucleotides arranged in a double helix. It encodes the instructions for protein synthesis and cellular functions, playing a fundamental role in all aspects of human biology.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 71F12"
See other products for "DNA"
Select a product category from the dropdown menu below to view related products.
Please select product type
ScFv Antibody Products
Fab Antibody Products
Mouse Antibody Products
Humanized Antibody Products
IgG Antibody Products
IgM Antibody Products
Autoantibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-074 | Mouse Anti-DNA Recombinant Antibody; scFv Fragment (PSBL-074) | ELISA, WB, FuncS | Mouse scFv |
| PSBL-075 | Mouse Anti-DNA Recombinant Antibody (clone ED10); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| PSBC-033 | Mouse Anti-DNA Recombinant Antibody (clone 64M-2); scFv Fragment | ELISA, WB | Mouse scFv |
| FAMAB-0075CQ-S(P) | Mouse Anti-DNA Recombinant Antibody (clone 16-13); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0076CQ-S(P) | Mouse Anti-DNA Recombinant Antibody (clone 1A11); scFv Fragment | ELISA | Mouse scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY165. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application:
Application: WB, Neut, FuncS
-YJ-1.jpg)
Application: ELISA
Application: IHC, ELISA, FC, WB, ADCC, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: ELISA, IHC, IF, IP, FC, FuncS
Application: ELISA, IHC, IF, IP
Application: ELISA, FC, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
