Human Anti-DPP6 scFv-Fc Chimera (VS-0125-FY75) (CAT#: VS-0125-FY75)
The ANTI-DPP6 scFv-Fc, a single-chain antibody-fusion protein targeting dipeptidyl peptidase 6 (DPP6), serves as a significant tool in biomedical research for understanding the biological functions of DPP6 and its roles in various diseases, with applications in fundamental research, drug development, and mechanisms of diseases, particularly in the fields of neuroscience, immunology, and oncology.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/ihc_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/126326_A_8_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/126326_A_8_4_val_selected.jpg
Figure 3 Cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/126326_B_7_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/126326_B_7_5.jpg
Figure 4 Smooth muscle
(Smooth muscle cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/126326_B_6_7.jpg
(Smooth muscle cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50509/126326_B_6_7.jpg
Figure 5 RNA cell line category: Cell line enriched (NTERA-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000130226-DPP6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000130226-DPP6
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Applications
- Inhibition
- Related Disease
- Neurodegenerative disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The ANTI-DPP6 scFv-Fc functions by specifically binding to the DPP6 protein, making it valuable for studying DPP6-related functions and mechanisms; it may inhibit or regulate the activity of DPP6 through its binding, thereby influencing associated signaling pathways or cellular processes, and it has potential applications in drug development as DPP6 is involved in various physiological and pathological processes.
Target
- Alternative Names
- Dipeptidyl Peptidase Like 6; Dipeptidyl Peptidase VI; Dipeptidyl-Peptidase 6; Dipeptidyl Peptidase 6; DPP VI; DPPX; Dipeptidyl Aminopeptidase IV-Related Protein; Dipeptidyl Aminopeptidase-Related Protein; Dipeptidyl Aminopeptidase-Like Protein 6
- Gene ID
- 1804
- UniProt ID
- P42658
- Sequence Similarities
- Belongs to the peptidase S9B family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn173, Asn319, Asn404, Asn471, Asn535, Asn566, and Asn813
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 5 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016867301.1; XP_047275907.1; XP_054213391.1; NP_001034439.1; NP_001277181.1
- Function
- Promotes cell surface expression of the potassium channel KCND2.
Modulates the activity and gating characteristics of the potassium channel KCND2.
Has no dipeptidyl aminopeptidase activity.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3967z | Mouse Anti-DPP6 Recombinant Antibody (clone 24D8) | WB, IP, IF, ELISA | Mouse IgG2a, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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