Human Anti-DSC1 scFv-Fc Chimera (VS-0425-FY19) (CAT#: VS-0425-FY19)
This anti-DSC1 single-chain antibody fragment-Fc fusion protein (anti-DSC1 scFv-Fc) exhibits high specificity, selectively binding to desmoglein 1 (Dsg1) while displaying no binding activity to desmoglein 3 (Dsg3). This characteristic indicates the antibody's exceptional targeting capability, enabling precise identification and study of Dsg1's biological functions and pathological significance.
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Normal Tissue
Figure 1 High expression in skin 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_1_val_selected.jpg
Figure 2 Low expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_3_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_3_3_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_5.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_8_5.jpg
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_6_6.jpg
Specifications
- Immunogen
- Desmoglein pathogen as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It binds to Dsg1 (desmoglein 1), and it does not bind to Dsg3. It also does not bind mouse skin.
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Subcorneal Pustular Dermatosis; Iga Pemphigus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 0.5-20 ng/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Desmocollin 1; Desmosomal Glycoprotein 2/3; Cadherin Family Member 1; DG2/DG3; CDHF1; Desmocollin-1
- Gene ID
- 1823
- UniProt ID
- Q08554
- Long Name
- Desmocollin 1
- Cellular Localization
- Cell membrane, Cell junction, Desmosome
- Post Translation Modifications
- Glycosylation at Asn165 and Asn546
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054174211.1; NP_004939.1
- Function
- Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "DSC1"
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3293z | Mouse Anti-DSC1 Recombinant Antibody (clone 21D11) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| HPAB-0020-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0020-LSX) | ELISA | Human IgG |
| HPAB-0021-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0021-LSX) | ELISA | Human IgG |
| HPAB-0022-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0022-LSX) | ELISA | Human IgG |
| VS3-XY3337 | Rabbit Anti-DSC1 Recombinant Antibody (clone R93-2A-4) | WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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