Human Anti-DSC1 scFv-Fc Chimera (VS-0425-FY19) (CAT#: VS-0425-FY19)

• Immunogen
• Desmoglein pathogen as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• It binds to Dsg1 (desmoglein 1), and it does not bind to Dsg3. It also does not bind mouse skin.

• Species Reactivity
• Human

• Applications
• ELISA

• Related Disease
• Subcorneal Pustular Dermatosis; Iga Pemphigus

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 0.5-20 ng/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Desmocollin 1; Desmosomal Glycoprotein 2/3; Cadherin Family Member 1; DG2/DG3; CDHF1; Desmocollin-1

• Gene ID
• 1823

• UniProt ID
• Q08554

• Long Name
• Desmocollin 1

• Cellular Localization
• Cell membrane, Cell junction, Desmosome

• Post Translation Modifications
• Glycosylation at Asn165 and Asn546
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 9 sites, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_054174211.1; NP_004939.1

• Function
• Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

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