Human Anti-DSG3 (clone DF366) scFv-Fc Chimera (CAT#: VS-0125-FY74)
The anti-DSG3 (Desmoglein 3) scFv-Fc antibody is a genetically engineered monoclonal antibody that combines a single-chain variable fragment (scFv) specific to DSG3 with the Fc portion of an IgG antibody. This design enhances the stability and half-life of the antibody while preserving its ability to bind specifically to DSG3, a protein that plays a crucial role in the adhesion of epithelial cells within the skin and mucous membranes.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Esophagus
(Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56863/148897_B_5_1.jpg
(Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56863/148897_B_5_1.jpg
Figure 2 RNA cell line category: Group enriched (HaCaT, hTCEpi)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134757-DSG3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134757-DSG3
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- DF366
- Applications
- Immunohistochemistry, Flow Cytometry
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- anti-DSG3 scFv-Fc is a promising therapeutic approach that targets the underlying causes of certain autoimmune diseases, with the potential to improve patient outcomes by restoring cell adhesion and reducing inflammation.
Target
- Alternative Names
- Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen; Desmoglein-3
- Gene ID
- 1830
- UniProt ID
- P32926
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Cell junction, desmosome
- Post Translation Modifications
- Glycosylation at Asn110, Asn180, Asn459, Asn545, Thr601, and Thr602
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 12 sites, 2 O-linked glycans (5 sites)
- Protein Refseq
- XP_011524152.1; XP_054174213.1; NP_001935.2
- Function
- Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "DSG3"
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Please select product type
Mouse Antibody Products
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Fab Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-258MZ | Anti-Human DSG3 Recombinant Antibody (TAB-258MZ) | IHC, FC | |
| TAB-259MZ | Anti-Human DSG3 Recombinant Antibody (TAB-259MZ) | IHC, FC | |
| TAB-260MZ | Anti-Human DSG3 Recombinant Antibody (TAB-260MZ) | IHC, FC | |
| TAB-258MZ-F(E) | Anti-Human DSG3 Recombinant Antibody Fab Fragment (TAB-258MZ-F(E)) | IHC, FC | |
| TAB-259MZ-F(E) | Anti-Human DSG3 Recombinant Antibody Fab Fragment (TAB-259MZ-F(E)) | IHC, FC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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