Human Anti-DSG3 (clone DF366) scFv-Fc Chimera
CAT#: VS-0125-FY74
The anti-DSG3 (Desmoglein 3) scFv-Fc antibody is a genetically engineered monoclonal antibody that combines a single-chain variable fragment (scFv) specific to DSG3 with the Fc portion of an IgG antibody. This design enhances the stability and half-life of the antibody while preserving its ability to bind specifically to DSG3, a protein that plays a crucial role in the adhesion of epithelial cells within the skin and mucous membranes.
Gene Expression
Normal Tissue
Figure 1 Esophagus
Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56863/148897_B_5_1.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HaCaT, hTCEpi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134757-DSG3
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- DF366
- Applications
- Immunohistochemistry, Flow Cytometry
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- anti-DSG3 scFv-Fc is a promising therapeutic approach that targets the underlying causes of certain autoimmune diseases, with the potential to improve patient outcomes by restoring cell adhesion and reducing inflammation.
Target
- Alternative Names
- Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen; Desmoglein-3
- Gene ID
- 1830
- UniProt ID
- P32926
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Cell junction, desmosome
- Post Translation Modifications
- Glycosylation at Asn110, Asn180, Asn459, Asn545, Thr601, and Thr602
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 12 sites, 2 O-linked glycans (5 sites)
- Protein Refseq
- XP_011524152.1; XP_054174213.1; NP_001935.2
- Function
- Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "DSG3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-172 | Human Anti-DSG3 Recombinant Antibody (clone PVA3) | ELISA | Human IgG |
| FAMAB-1111CQ | Human Anti-DSG3 Recombinant Antibody (clone PVA224) | IF, ELISA, IHC | Human IgG1 |
| FAMAB-1113CQ | Mouse Anti-DSG3 Recombinant Antibody (clone PVB28) | IF, ELISA, IHC | Mouse IgG1 |
| FAMAB-1114CQ | Human Anti-DSG3 Recombinant Antibody (clone PVA232) | ELISA | Human IgG1 |
| FAMAB-1115CQ | Human Anti-DSG3 Recombinant Antibody (clone PVB16) | IF, ELISA, IHC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1055 | Hi-Affi™ Rabbit Anti-DSG3 Recombinant Antibody (clone DS1055AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0205-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0152JF-S(P) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); scFv Fragment | IF, WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0205-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0152JF-F(E) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); Fab Fragment | IF, WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC193 | Recombinant Anti-DSG3 Vesicular Antibody, EV Displayed (VS-0425-YC193) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2095 | Anti-DSG3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2096 | Anti-Mouse DSG3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC50 | Recombinant Anti-DSG3 (EC1 domain x EC2 domain) Biparatopic Antibody, Tandem scFv (Clone PVA224 x Clone PVB28) | ELISA, IF, IHC | Tandem scFv |
| VS-0525-YC52 | Recombinant Anti-DSG3 (EC3 domain x EC5 domain) Biparatopic Antibody, Tandem scFv (Clone PVA218 x Clone PVA232) | ELISA | Tandem scFv |
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