Human Anti-EphA5 (clone 11C12) scFv-Fc Chimera (CAT#: VS-0325-FY178)
The anti-EphA5 scFv-Fc antibody is designed to target EphA5, a member of the Eph receptor family involved in cell signaling and development. This antibody combines the specificity of the single-chain variable fragment (scFv)with the stability and extended half-life provided by the Fc region, making it suitable for applications in research and potential therapeutic development targeting EphA5-mediated pathways.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (hTERT-RPE1, PC-3, TIME, U-138 MG, U-2197, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145242-EPHA5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145242-EPHA5
Specifications
- Immunogen
- EphA polypeptide
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The epitope recognized by the 11C12 antibody is found within the 304-467 region of the hEphA5 protein.
- Species Reactivity
- Human
- Clone
- 11C12
- Applications
- ELISA, Inhibition
- Related Disease
- Lung cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- EPH Receptor A5; Brain-Specific Kinase; EPH Homology Kinase 1; EPH-Like Kinase 7; EC 2.7.10.1; TYRO4; EHK-1; EHK1; HEK7
- Gene ID
- 2044
- UniProt ID
- P54756
- Long Name
- EPH Receptor A5
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
- Cellular Localization
- Cell membrane; Cell projection, axon; Cell projection, dendrite
- Post Translation Modifications
- Phosphorylated.
Phosphorylation is stimulated by the ligand EFNA5.
Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity).
Glycosylation at Asn264, Asn299, Asn369, Asn423, Asn436, and Asn461
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 3 N-linked glycans (3 sites)
- Protein Refseq
- XP_005265710.1; XP_011530037.1; XP_016863367.1; XP_016863369.1; XP_016863370.1
- Function
- Human EphA5 (Eph receptor A5) is a receptor tyrosine kinase involved in cell signaling, particularly in neuronal development and axon guidance. It plays a role in tissue boundary formation and is implicated in various cancers.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0653CT | Recombinant Mouse anti-Human EPHA5 Monoclonal antibody (9C20C2,9C20G6) | ELISA, WB | |
| HPAB-0010-WJ | Mouse Anti-EPHA5 Recombinant Antibody (clone 11C12) | ELISA | Mouse IgG1 |
| ZG-0296J | Mouse Anti-EPHA5 Recombinant Antibody (ZG-0296J) | WB, ELISA | Mouse IgG |
| VS3-QX372 | Mouse Anti-EPHA5 Recombinant Antibody (clone 46CT61.6.4) | WB, IHC | Mouse IgG1, κ |
| VS7-HM873 | Mouse Anti-EPHA5 Recombinant Antibody (clone CBL236HM) | WB, ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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