Human Anti-F11R (clone 6F4) scFv-Fc Chimera
CAT#: VS-0325-FY20
The anti-F11R scFv-Fc antibody is a type of engineered therapeutic antibody that targets F11R (also known as junctional adhesion molecule A, JAM-A), a protein involved in cell adhesion and inflammatory processes.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions & microtubules.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to microtubules.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/1026_E7_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to microtubules.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/965_H10_1_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_4.jpg
Normal Tissue
Figure 7 Kidney
Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_6_6.jpg
Normal Tissue
Figure 9 Skin
Epidermal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_4_8.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (HaCaT, OE19, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000158769-F11R
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human F11R
- Species Reactivity
- Human
- Clone
- 6F4
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- F11 Receptor; Junctional Adhesion Molecule 1; Platelet Adhesion Molecule 1; Platelet F11 Receptor; PAM-1; JAM1; JCAM; Junctional Adhesion Molecule A
- Gene ID
- 50848
- UniProt ID
- Q9Y624
- Long Name
- F11 Receptor
- Sequence Similarities
- Belongs to the immunoglobulin superfamily.
- Cellular Localization
- Cell junction, tight junction; Cell membrane
- Post Translation Modifications
- N-glycosylated.
(Microbial infection) Cleaved by H.pylori virulence factor PqqE.
Cleavage leads to altered tight junction functions.
Glycosylation at Thr175 and Asn185
Ubiquitination at Lys97 and Lys277
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect JAM1_HUMAN (1427)
Glycosylation from GlyGen 4 sites, 14 N-linked glycans (1 site), 2 O-linked glycans (3 sites)
- Protein Refseq
- NP_001335020.1; NP_001369656.1; NP_001369659.1; NP_001369662.1; NP_001369663.1
- Function
- Seems to play a role in epithelial tight junction formation.
Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913).
The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).
Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity).
Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992).
Involved in platelet activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone 6F4"
- CAT
- Product Name
See other products for "F11R"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-914-VHH | Recombinant Anti-Human F11R VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0606CL | Anti-Human JAM-A Recombinant Antibody (TAB-0606CL) | IF, IHC, FC, WB | |
| TAB-0606CL-S(P) | Anti-Human F11R Recombinant Antibody scFv Fragment (6F4) | ELISA | |
| TAB-0606CL-F(E) | Anti-Human F11R Recombinant Antibody Fab Fragment (6F4) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1223 | Hi-Affi™ Rabbit Anti-F11R Recombinant Antibody (clone DS1223AB) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0298-CN | Human Anti-F11R Recombinant Antibody (clone Hz6F4-2) | ELISA, WB, IF | Humanized IgG4, κ |
| HPAB-0297-CN | Human Anti-F11R Recombinant Antibody (clone ch6F4) | ELISA, WB, IF | Chimeric (mouse/human) IgG4, κ |
| HPAB-0137-FY | Recombinant Human Anti-F11R Antibody (Hz6F4-2) | In vivo activity | Human IgG4, κ |
| MOR-0021-FY | Mouse Anti-F11R Recombinant Antibody (clone M.Ab.F11) | FC, FuncS, IF, IP, WB | Mouse IgG1 |
| VS3-WK1232 | Rabbit Anti-F11R Recombinant Antibody (VS3-WK1232) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0298-CN-S(P) | Human Anti-JAM-A Recombinant Antibody; scFv Fragment (HPAB-0298-CN-S(P)) | ELISA, WB, IF | Humanized scFv |
| HPAB-0137-FY-S(P) | Recombinant Human Anti-F11R Antibody scFv Fragment (Hz6F4-2) | In vivo activity | Human scFv |
| HPAB-0880-FY-F(E) | Mouse Anti-F11R Recombinant Antibody (clone 6F4); scFv Fragment | Activ | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0297-CN-F(E) | Human Anti-JAM-A Recombinant Antibody; Fab Fragment (HPAB-0297-CN-F(E)) | ELISA, WB, IF | Chimeric (mouse/human) Fab |
| HPAB-0298-CN-F(E) | Human Anti-F11R Recombinant Antibody; Fab Fragment (HPAB-0298-CN-F(E)) | ELISA, WB, IF | Humanized Fab |
| HPAB-0137-FY-F(E) | Recombinant Human Anti-F11R Antibody Fab Fragment (Hz6F4-2) | In vivo activity | Human Fab, κ |
| HPAB-0171CQ-F(E) | Rat Anti-F11r Recombinant Antibody (clone MAb BV12); Fab Fragment | WB, IP, IF | Rat Fab |
| HPAB-0880-FY-S(P) | Mouse Anti-F11R Recombinant Antibody (clone 6F4); Fab Fragment | Activ | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1455 | AbPlus™ Anti-F11R Magnetic Beads (VS-0724-YC1455) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY110 | CytoStream™ Rat Anti-F11R Recombinant Antibody (clone H202-106) | FC | Rat IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC325 | Recombinant Anti-F11R Vesicular Antibody, EV Displayed (VS-0425-YC325) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2402 | Anti-F11R Immunohistochemistry Kit | IHC | |
| VS-0525-XY2403 | Anti-Mouse F11R Immunohistochemistry Kit | IHC |
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