Human Anti-F11R (clone 6F4) scFv-Fc Chimera (CAT#: VS-0325-FY20)
The anti-F11R scFv-Fc antibody is a type of engineered therapeutic antibody that targets F11R (also known as junctional adhesion molecule A, JAM-A), a protein involved in cell adhesion and inflammatory processes.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions & microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions & microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/if_selected.jpg
Figure 2 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/1026_E7_1_red_green.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/1026_E7_1_red_green.jpg
Figure 3 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/965_H10_1_red_green.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/965_H10_1_red_green.jpg
Figure 4 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_8_5.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_8_5.jpg
Figure 5 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_9_3.jpg
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_9_3.jpg
Figure 6 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_4.jpg
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_4.jpg
Figure 7 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_7_5.jpg
(Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_7_5.jpg
Figure 8 Testis
(Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_6_6.jpg
(Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_6_6.jpg
Figure 9 Skin
(Epidermal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_4_8.jpg
(Epidermal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_4_8.jpg
Figure 10 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_8.jpg
Figure 11 RNA cell line category: Cell line enhanced (HaCaT, OE19, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000158769-F11R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000158769-F11R
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human F11R
- Species Reactivity
- Human
- Clone
- 6F4
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- F11 Receptor; Junctional Adhesion Molecule 1; Platelet Adhesion Molecule 1; Platelet F11 Receptor; PAM-1; JAM1; JCAM; Junctional Adhesion Molecule A
- Gene ID
- 50848
- UniProt ID
- Q9Y624
- Long Name
- F11 Receptor
- Sequence Similarities
- Belongs to the immunoglobulin superfamily.
- Cellular Localization
- Cell junction, tight junction; Cell membrane
- Post Translation Modifications
- N-glycosylated.
(Microbial infection) Cleaved by H.pylori virulence factor PqqE.
Cleavage leads to altered tight junction functions.
Glycosylation at Thr175 and Asn185
Ubiquitination at Lys97 and Lys277
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect JAM1_HUMAN (1427)
Glycosylation from GlyGen 4 sites, 14 N-linked glycans (1 site), 2 O-linked glycans (3 sites)
- Protein Refseq
- NP_001335020.1; NP_001369656.1; NP_001369659.1; NP_001369662.1; NP_001369663.1
- Function
- Seems to play a role in epithelial tight junction formation.
Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913).
The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).
Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity).
Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992).
Involved in platelet activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| NAB-914-VHH | Recombinant Anti-Human F11R VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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