Human Anti-FCER1A scFv-Fc Chimera (VS-0425-FY119) (CAT#: VS-0425-FY119)
Anti-FCER1A scFv-Fc is a recombinant antibody targeting the alpha subunit of the high-affinity IgE receptor (FCER1A) found on mast cells and basophils. The scFv provides specific binding to FCER1A, while the Fc region offers stability and potential for dimerization. This format is being developed to block IgE binding to FCER1A, thereby inhibiting downstream allergic responses and inflammation.
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Normal Tissue
RNA Expression
Figure 1 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55526/130432_A_8_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55526/130432_A_8_4.jpg
Figure 2 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55526/130432_A_7_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55526/130432_A_7_5.jpg
Figure 3 RNA cell line category: Cell line enriched (HEL)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000179639-FCER1A
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000179639-FCER1A
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human FCER1A
- Species Reactivity
- Human
- Applications
- Inhibition
- Related Disease
- Chronic Urticaria and Chronic Spontaneous Urticaria
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Fc Fragment Of IgE Receptor Ia; Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide; IgE Fc Receptor Subunit Alpha; Fc Epsilon Receptor Ia; Fc-Epsilon RI-Alpha; FCE1A; FcERI
- Gene ID
- 2205
- UniProt ID
- P12319
- Long Name
- Fc Fragment Of IgE Receptor Ia
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn46, Asn67, Asn75, Asn99, Asn160, Asn165, and Asn191
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites
- Protein Refseq
- NP_001374209.1; NP_001374210.1; NP_001374211.1; NP_001992.1
- Function
- High-affinity receptor for immunoglobulin epsilon/IgE.
Mediates IgE effector functions in myeloid cells.
Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation.
On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes.
Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity.
Related Resources
Asthma
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FCER1A"
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Human Antibody Products
IgG Antibody Products
Neutralizing Antibody Products
ScFv Antibody Products
Fab Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-033WM | Human Anti-FCER1A Recombinant Antibody (TAB-033WM) | ELISA | Human IgG |
| TAB-033WM-S(P) | Human Anti-FCER1A Recombinant Antibody; scFv Fragment (TAB-033WM-S(P)) | ELISA | Human scFv |
| TAB-033WM-F(E) | Human Anti-FCER1A Recombinant Antibody; Fab Fragment (TAB-033WM-F(E)) | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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