Human Anti-FCER1A scFv-Fc Chimera (VS-0425-FY119)
CAT#: VS-0425-FY119
Anti-FCER1A scFv-Fc is a recombinant antibody targeting the alpha subunit of the high-affinity IgE receptor (FCER1A) found on mast cells and basophils. The scFv provides specific binding to FCER1A, while the Fc region offers stability and potential for dimerization. This format is being developed to block IgE binding to FCER1A, thereby inhibiting downstream allergic responses and inflammation.
Gene Expression
Normal Tissue
Figure 1 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55526/130432_A_8_4.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55526/130432_A_7_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HEL)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000179639-FCER1A
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human FCER1A
- Species Reactivity
- Human
- Applications
- Inhibition
- Related Disease
- Chronic Urticaria and Chronic Spontaneous Urticaria
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Fc Fragment Of IgE Receptor Ia; Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide; IgE Fc Receptor Subunit Alpha; Fc Epsilon Receptor Ia; Fc-Epsilon RI-Alpha; FCE1A; FcERI
- Gene ID
- 2205
- UniProt ID
- P12319
- Long Name
- Fc Fragment Of IgE Receptor Ia
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn46, Asn67, Asn75, Asn99, Asn160, Asn165, and Asn191
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites
- Protein Refseq
- NP_001374209.1; NP_001374210.1; NP_001374211.1; NP_001992.1
- Function
- High-affinity receptor for immunoglobulin epsilon/IgE.
Mediates IgE effector functions in myeloid cells.
Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation.
On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes.
Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity.
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Related Diseases
Asthma
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FCER1A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-033WM | Human Anti-FCER1A Recombinant Antibody (TAB-033WM) | ELISA | Human IgG |
| TAB-033WM-S(P) | Human Anti-FCER1A Recombinant Antibody; scFv Fragment (TAB-033WM-S(P)) | ELISA | Human scFv |
| TAB-033WM-F(E) | Human Anti-FCER1A Recombinant Antibody; Fab Fragment (TAB-033WM-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-784CQ | Mouse Anti-FCER1A Recombinant Antibody (clone CBL651) | FC, CyTOF®, Neut | Mouse IgG2b |
| NEUT-785CQ | Hamster Anti-Fcer1a Recombinant Antibody (clone MAR-1) | FC, FuncS, Neut | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1142-FY | Mouse Anti-FCER1A Recombinant Antibody (clone 4-12C) | ELISA | Mouse IgG |
| HPAB-1143-FY | Mouse Anti-FCER1A Recombinant Antibody (clone 2-3A) | ELISA | Mouse IgG |
| HPAB-1144-FY | Mouse Anti-FCER1A Recombinant Antibody (clone 5-1D) | ELISA | Mouse IgG |
| HPAB-1145-FY | Mouse Anti-FCER1A Recombinant Antibody (clone 4-9E) | ELISA | Mouse IgG |
| HPAB-1146-FY | Mouse Anti-FCER1A Recombinant Antibody (clone 7-3C) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1142-FY-F(E) | Mouse Anti-FCER1A Recombinant Antibody (clone 4-12C); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1143-FY-F(E) | Mouse Anti-FCER1A Recombinant Antibody (clone 2-3A); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0279JF-S(P) | Human Anti-FCER1A Recombinant Antibody (clone CBMalpha8); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-1534WJ-S(P) | Human Anti-FCER1A Recombinant Antibody; scFv Fragment (clone CRA2) | ELISA, WB | Human scFv |
| HPAB-1535WJ-S(P) | Human Anti-FCER1A Recombinant Antibody; scFv Fragment (clone CRA4) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1142-FY-S(P) | Mouse Anti-FCER1A Recombinant Antibody (clone 4-12C); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1143-FY-S(P) | Mouse Anti-FCER1A Recombinant Antibody (clone 2-3A); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1144-FY-S(P) | Mouse Anti-FCER1A Recombinant Antibody (clone 5-1D); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1145-FY-S(P) | Mouse Anti-FCER1A Recombinant Antibody (clone 4-9E); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1146-FY-S(P) | Mouse Anti-FCER1A Recombinant Antibody (clone 7-3C); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC742 | Recombinant Anti-FCER1A Vesicular Antibody, EV Displayed (VS-0425-YC742) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2475 | Anti-Mouse FCER1A Immunohistochemistry Kit | IHC |
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