Human Anti-FCER1A scFv-Fc Chimera (VS-0425-FY119) (CAT#: VS-0425-FY119)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human FCER1A

• Species Reactivity
• Human

• Applications
• Inhibition

• Related Disease
• Chronic Urticaria and Chronic Spontaneous Urticaria

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Fc Fragment Of IgE Receptor Ia; Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide; IgE Fc Receptor Subunit Alpha; Fc Epsilon Receptor Ia; Fc-Epsilon RI-Alpha; FCE1A; FcERI

• Gene ID
• 2205

• UniProt ID
• P12319

• Long Name
• Fc Fragment Of IgE Receptor Ia

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Glycosylation at Asn46, Asn67, Asn75, Asn99, Asn160, Asn165, and Asn191
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 7 sites

• Protein Refseq
• NP_001374209.1; NP_001374210.1; NP_001374211.1; NP_001992.1

• Function
• High-affinity receptor for immunoglobulin epsilon/IgE.
  Mediates IgE effector functions in myeloid cells.
  Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation.
  On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes.
  Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity.

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