Human Anti-FN1 (clone L19) scFv-Fc Chimera (CAT#: VS-0425-FY108)

• Immunogen
• The immunogen used for selecting the L19 antibody was the recombinant ED-B domain of fibronectin.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• It is specific for the ED-B domain of fibronectin.

• Species Reactivity
• Human

• Clone
• L19

• Applications
• Immunohistochemistry, ELISA, Immunofluorescence

• Related Disease
• Inflammatory disease, psoriasis, Crohn's disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Fibronectin 1; Cold-Insoluble Globulin; Migration-Stimulating Factor; CIG; FN; Fibronectin; GFND2; SMDCF

• Gene ID
• 2335

• UniProt ID
• P02751

• Long Name
• Fibronectin 1

• Cellular Localization
• Secreted

• Post Translation Modifications
• Sulfated.
  Phosphorylated by FAM20C in the extracellular medium.
  Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
  Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.
  Serotonylated on Gln residues by TGM2 in response to hypoxia.
  Glycosylation at Thr278, Thr279, Ser280, Ser281, Ser283, Thr287, Asn430, Asn528, Asn542, Asn877, Asn1007, Asn1236, Asn1244, Thr1367, Asn1291, Ser1656, Ser1657, Ser1658, Thr1661, Thr1732, Thr2151, Thr2152, Thr2155, Thr2156, Thr2158, Thr2090, Ser2432, Thr2436, Thr2437, Ser2440, and Asn2199
  Ubiquitination at Lys1050
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect FINC_HUMAN (161)
  Glycosylation from GlyGen 32 sites, 272 N-linked glycans (9 sites), 7 O-linked glycans (19 sites)

• Protein Refseq
• NP_001293058.2; NP_001293059.2; NP_001293060.2; NP_001293061.2; NP_001352446.1

• Function
• Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin.
  Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.
  Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
  Participates in the regulation of type I collagen deposition by osteoblasts.
  Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation.

• ACFP-SH081
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-IL4

• ACFP-SH082
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-VEGF

• ACFP-SH083
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-GM-CSF

• ACFP-SH084
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-IFNγ

• ACFP-SH085
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-IL10

• ACFP-SH088
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv-CH4 (L19)-IL12

• ACFP-SH089
• Anti-EDB Antibody-Cytokine Fusion Protein, IL12-scFv (L19)

• ACFP-SH090
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-IL15

• ACFP-SH092
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-TNFα

• ACFP-SH140
• Anti-EDB Antibody-Cytokine Fusion Protein, scIL12-scFv-CH4 (L19)

• ACFP-SH156
• Anti-EDB Antibody-Cytokine Fusion Protein, GM-CSF-scFv (L19)-scFv (L19)-GM-CSF

• ACFP-SH157
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-IL12-scFv (L19)

• ACFP-SH158
• Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-IL2

• ACFP-SH159
• Anti-EDB Antibody-Cytokine Fusion Protein, IL2-scFv (L19)

• ACFP-SH164
• Anti-EDB Antibody-Cytokine Fusion Protein, GM-CSF-scFv (L19)

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